Actively Recruiting
DOvEEgene/WISE Genomics: Diagnosing Ovarian and Endometrial Cancer Early Using Genomics
Led by McGill University · Updated on 2025-06-18
1200
Participants Needed
1
Research Sites
665 weeks
Total Duration
On this page
Sponsors
M
McGill University
Lead Sponsor
M
McGill University Health Centre/Research Institute of the McGill University Health Centre
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study aims to develop and validate a test for detecting ovarian and endometrial cancers early. It relies on detecting somatic mutations that are associated with these cancers from a uterine pap test. A saliva sample is also collected that acts as an internal control and has the ability to detect deleterious germline mutations associated with common hereditary cancers (such as breast, ovarian, endometrial, colon, and pancreatic cancers). A machine learning classifier is then used to discriminate between cancer and benign disease.
CONDITIONS
Official Title
DOvEEgene/WISE Genomics: Diagnosing Ovarian and Endometrial Cancer Early Using Genomics
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female subjects with suspected or confirmed cancer of the upper genital tract
- Participants who will undergo surgery for tumor removal
- Female subjects scheduled to have a hysterectomy, bilateral salpingectomy, with or without bilateral oophorectomy, for presumed benign disease
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
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Trial Site Locations
Total: 1 location
1
Royal Victoria Hospital (Glen Site)
Montreal, Quebec, Canada, H4A 3J1
Actively Recruiting
Research Team
D
Dr. Lucy Gilbert, MD,MSc,FRCOG
CONTACT
D
Dr. Claudia Martins, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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