Evaluating Precision and Reliability of DXA and pQCT Scans for Adult Bone and Body Composition Assessment

What this Trial Is About

This research aims to evaluate the precision and reliability of three scanning devices the GE Lunar iDXA, Hologic Horizon W DXA, and the Stratec peripheral quantitative computed tomography pQCT scanner. The study focuses on measuring bone mineral content, bone geometry, and soft tissues in both inanimate objects and adults. It assesses variability in testing due to factors like day-to-day changes, technician differences, positioning, and different equipment, while also establishing the least significant change for these measurements and examining device strengths and limitations. Participants undergo precision testing using the DXA devices and pQCT scanner, which measure bone mineral density and body composition including fat mass and lean mass. The study uses standard protocols to scan regions prone to fractures or responsive to interventions. The pQCT provides 3D imaging to assess bone strength components separately. This testing helps ensure quality control and cross-calibration of scanners across sites. During the study, participants will have multiple scans performed to evaluate measurement reproducibility. Researchers will monitor scan precision and variability related to technicians and equipment. The primary outcomes include precision measurements and least significant change of bone mineral density and body composition within one month. The study spans multiple visits with no treatment administered, focusing on observation and data collection to build a database of test results and quality control procedures.

DXA Study of Precision and Reliability