Actively Recruiting
Dynamic Cardio-, Cerebro-vascular and Cortical Interaction in Healthy Adult Subjects
Led by IRCCS Policlinico S. Donato · Updated on 2025-03-28
50
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to evaluate the interaction of heart, brain, and blood vessel functions in healthy adults. It focuses on understanding how autonomic function, cerebral blood flow regulation, and brain activity relate to psychological aspects like depressive symptoms. The study involves healthy volunteers to better characterize these physiological and psychological relationships. Participants will undergo simultaneous monitoring of brain waves (EEG), heart signals (ECG), blood pressure, respiratory movements, and cerebral blood flow using transcranial Doppler and Laser-Doppler devices. The study includes three 10-minute sessions: resting in a lying down position, standing up to test autonomic reflexes, and watching short emotional video clips to assess cortical and cardiovascular responses. The entire experiment lasts about 30 minutes. Volunteers will be assessed with psychometric tests to check for depressive symptoms alongside physiological recordings. Researchers will measure outcomes like autoregulation index, baroreflex sensitivity, and cortical activity over a period of 36 months. This includes careful monitoring of cardiovascular, cerebrovascular, and cortical functions during different conditions for comprehensive evaluation.
CONDITIONS
Brief Title
Dynamic Cardio-vascular, Cerebro-vascular and Cortical Interaction in Healthy Adult Subjects
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age older than 18 years
- Spontaneous sinus rhythm
- Signed informed consent
You will not qualify if you...
- Definite diseases of the Autonomic Nervous System or the cardiovascular system
- Central nervous system disorders
- Subjects under drug therapy that may affect the cardiovascular system
- Pregnancy
- Previous diagnosis of depression
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo a 30-minute experimental protocol including physiological data recordings during three 10-minute sessions: resting state in supine position, active standing to evoke reflex sympathetic activation, and emotional elicitation via video administration.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
IRCCS Policlinico San Donato
San Donato Milanese, Milano, Italy, 20097
Actively Recruiting
Research Team
V
Vlasta Bari, PhD
P
Pavandeep Singh
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
1
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