Actively Recruiting
Early Neurophysiological Markers of Language Impairments: a Longitudinal Study on Infants At Familial Risk
Led by IRCCS Eugenio Medea · Updated on 2025-02-05
100
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to identify very early brain activity markers that may indicate risk for language impairments in children. It focuses on tracking developmental learning patterns in infants who have a family history of language difficulties. The study follows children from infancy through school age to understand how early neurophysiological processes relate to later reading and spelling abilities. Participants undergo electrophysiological recordings at 6, 12, and 24 months to capture early neural markers. Later, individual behavioral assessments are conducted at ages 3, 4.5, 6, and 8 years to evaluate language-related skills and development. The study includes infants from the Medea BabyLab cohort, with groups based on familial risk for language impairments. During the study, children are assessed on various language and cognitive skills including vocabulary, phonological awareness, memory, syntactic and lexical comprehension, letter knowledge, reading, and spelling at specific ages. Researchers also measure secondary outcomes like naming accuracy and visual-motor integration. The study monitors these developmental trajectories over several years to build a prognostic model predicting language outcomes based on early brain activity.
CONDITIONS
Brief Title
Early Neurophysiological Markers of Language Impairments
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy infants aged less than 24 months
- Infants with or without familial risk for language impairments (at least one first-degree relative with a clinical diagnosis of language impairment or learning disability)
- Both parents are native Italian speakers
You will not qualify if you...
- Gestational age less than 37 weeks and/or birth weight less than 2500 grams
- APGAR scores at birth less than 7 at 1 and 5 minutes
- Bayley Cognitive Score less than 7
- Certified diagnosis of intellectual deficiency, attention-deficit disorder, sensorial or neurological disorders, or autism in a first-degree relative
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - From 6 to 24 months of age
Participants undergo electrophysiological recordings to investigate early neural markers at 6, 12, and 24 months.
3 visits (in-person) at 6, 12, and 24 months
Duration - From 3 to 8 years of age
Participants receive individual behavioral assessments assessing language and cognitive development at later ages.
4 visits (in-person) at ages 3, 4.5, 6, and 8 years
Trial Site Locations
Total: 1 location
1
Associazione La Nostra Famiglia - IRCCS Eugenio Medea
Bosisio Parini, LC, Italy, 23842
Actively Recruiting
Research Team
C
Chiara Cantiani, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here