Development and Validation of Sepsis Recognition Tools for Children Under 18 Including the Phoenix Sepsis Score and SORT in Asian Healthcare Settings

What this Trial Is About

Researchers are studying early recognition tools designed for children under 18 years old with suspected infection to improve sepsis detection in diverse healthcare settings across Asia. This study focuses on evaluating the Phoenix sepsis scores ability to predict mortality risk and developing a new tool called the Sepsis Optimal Recognition Toolkit in children SORT. It also explores how feasible and acceptable it is to use Phoenix criteria in clinical practice and investigates conditions that mimic sepsis in children. The study involves two groups a retrospective cohort of children hospitalized with suspected infection from January 2020 to December 2025, and a prospective cohort from February 2026 to June 2028. Data collected include various clinical measurements within the first 24 hours of hospital admission, such as respiratory, cardiovascular, coagulation, neurological, endocrine, immune, renal, and liver function indicators. These data are used to apply the Phoenix Sepsis Score and develop the SORT tool. Participants contribute data to help evaluate sepsis recognition methods. Researchers link emergency and inpatient records to gather the worst clinical values during the first day of hospital stay. They measure how well the Phoenix score and SORT predict sepsis and mortality over two years. The study also examines the practicality of using the Phoenix criteria and looks into diseases that may mimic sepsis. The study is planned to continue until December 2028.

Early Sepsis Recognition Tool