Actively Recruiting
The Effect of Early Time-Restricted Eating on Cardiometabolic Health and Circadian Rhythms in Hypertensive Older Adults With Habitual Prolonged Eating Window
Led by University of Alabama at Birmingham · Updated on 2026-02-19
30
Participants Needed
1
Research Sites
26 weeks
Total Duration
On this page
Sponsors
U
University of Alabama at Birmingham
Lead Sponsor
U
UAB Nutrition Obesity Research Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating how early time-restricted eating affects body rhythms and cardiometabolic health in older adults with hypertension. The study focuses on adults aged 60 and older who have a habitual prolonged eating window and elevated blood pressure. The purpose is to understand if limiting eating to an earlier 8-hour window each day can improve health measures related to heart and metabolism. Participants in the study will be randomly assigned to either the early time-restricted eating group or a control group with no intervention. Those in the intervention group will fast for about 16 hours daily and eat freely within an 8-hour window starting between 6:30 and 8:30 am, six days a week for 12 weeks. During fasting, calorie-free drinks, sugar-free gum, and plenty of water are permitted. The study is single-blinded and conducted over a 12-week period. Throughout the study, participants will be monitored for changes in blood glucose, heart rate variability, and systolic blood pressure at the beginning and end of the 12 weeks. They will also be assessed for adherence to the eating schedule and overall health status. The research team will use these measurements to evaluate how early time-restricted eating influences cardiovascular and metabolic health in this population.
CONDITIONS
Brief Title
Early Time-Restricted Eating in Older Adults With Hypertension
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Consent to participate in the study
- Men and women 60 years old or older
- Average office systolic blood pressure of 130 mmHg or higher
- Self-reported eating period of 12 hours or less per day for at least 5 days per week
- Stable health history over the past 2 months
You will not qualify if you...
- Fasting more than 12 hours per day
- Actively trying to lose weight through a formal program or calorie restriction
- Weight loss of 10 pounds or more in the last 3 months
- Unable to wake up regularly between 6 and 8 am
- Performing overnight shift work more than one day per week on average
- Resting heart rate over 120 beats per minute
- Systolic blood pressure over 180 mmHg or diastolic blood pressure over 100 mmHg
- Diagnosed with diabetes
- Taking insulin or diabetes medication
- Unstable angina, heart attack, or stroke in the past 3 months
- Continuous use of supplemental oxygen for chronic lung or heart failure conditions
- Pregnant or breastfeeding
- Rheumatoid arthritis, Parkinson's disease, or currently on dialysis
- Major psychiatric condition impairing study participation
- Severe gastrointestinal disease, major gastrointestinal surgery, or active gallstone disease
- Active cancer treatment in the past year
- Taking medications that require food intake at least every 12 hours, preventing 16-hour fasting
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 12 weeks
Participants follow an early time-restricted eating schedule, fasting for 16 hours per day with an 8-hour eating window starting between 6:30-8:30 am, 6 days per week.
Weekly visits for 12 weeks
Trial Site Locations
Total: 1 location
1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35294
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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