Actively Recruiting
Effect of Beta-blockers on Coronary Flow and Resistance in Patients With ANOCA
Led by VZW Cardiovascular Research Center Aalst · Updated on 2025-07-14
46
Participants Needed
1
Research Sites
25 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn whether beta-blockers can improve coronary blood flow and reduce resistance in patients with angina and no obstructive coronary arteries (ANOCA). The main questions it aims to answer are: * Do beta-blockers improve coronary blood flow in patients with ANOCA? * Do beta-blockers reduce coronary microvascular resistance in these patients? Researchers will compare a beta-blocker to a placebo to see if the medication has measurable effects on coronary circulation. Participants will: * Receive a beta-blocker or a placebo * Undergo specialized heart tests (such as coronary flow and resistance measurements) before and after treatment.
CONDITIONS
Official Title
Effect of Beta-blockers on Coronary Flow and Resistance in Patients With ANOCA
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients undergoing diagnostic coronary angiography for suspected angina pectoris who are found to have ANOCA with an FFR >0.80 and no diameter stenosis >50%
- Normal TIMI 3 flow at angiography
- Stable haemodynamics
You will not qualify if you...
- Clinical signs or symptoms of congestive heart failure
- Severe valvular heart disease requiring surgical or percutaneous intervention
- History of coronary artery bypass grafting
- Tortuous coronary anatomy making wire manipulation complex
- Heart rate below 60 beats per minute
- Systolic blood pressure below 100 mmHg
- Unable to give consent
- Left ventricular ejection fraction (LVEF) below 40%
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
OLV Cardiovascular Center Aalst
Aalst, Flanders, Belgium, 9300
Actively Recruiting
Research Team
A
Adriaan Wilgenhof, MD
CONTACT
T
Thabo Mahendiran, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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