Impact of Routine Exercise on Gene Expression and Histone Changes in Adults Aged 25-70 With Stroke-Induced Hemiplegia

What this Trial Is About

Researchers are investigating how a routine exercise program affects neuroplasticity through changes in gene expression and histone acetylation in people who have recently experienced hemiplegia due to acute ischemic stroke. The study aims to understand how these epigenetic changes relate to motor function and quality of life improvements. This research focuses on stroke survivors undergoing rehabilitation to enhance brain recovery and motor skills through exercise. Participants will follow a routine rehabilitation program that includes 45 minutes of active and passive exercises such as range of motion, strengthening, balance exercises, walking training, and 20 minutes of bicycle ergometry. The program is supervised by experienced physiotherapists and tailored to the participants muscle strength, with sessions held five days a week over 30 sessions. Blood samples will be collected before and after the program to measure neuroplasticity-related gene expression and histone modification levels. During the study, participants will undergo evaluations before and after the exercise program, including cognitive tests, motor function assessments, spasticity measurements, independence scales, hand function questionnaires, stroke impact assessments, and walking tests. Researchers will analyze genetic and histone changes alongside clinical measures to assess the relationship between epigenetic effects and motor recovery. The study duration covers the baseline and 6-week post-treatment periods to monitor outcomes and safety throughout.

Effect of Exercise Gene Expression and Histone Modifications in Patients With Hemiplegia