A Review of Exercise-Induced Neuroplasticity in Ischemic Stroke: Pathology and Mechanisms.
Ying Xing, Yulong Bai
https://pubmed.ncbi.nlm.nih.gov/32691303Actively Recruiting
Phase Not Applicable
Age: 25Years - 70Years
All Genders
ID06726941
Effect of Exercise on Neuroplasticity-Related Gene Expression and Histone Modifications in Patients With Hemiplegia
Led by Afyonkarahisar Health Sciences University · Updated on 2025-11-25
48
Participants Needed
1
Research Sites
13 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating how a routine exercise program affects neuroplasticity through changes in gene expression and histone acetylation in people who have recently experienced hemiplegia due to acute ischemic stroke. The study aims to understand how these epigenetic changes relate to motor function and quality of life improvements. This research focuses on stroke survivors undergoing rehabilitation to enhance brain recovery and motor skills through exercise. Participants will follow a routine rehabilitation program that includes 45 minutes of active and passive exercises such as range of motion, strengthening, balance exercises, walking training, and 20 minutes of bicycle ergometry. The program is supervised by experienced physiotherapists and tailored to the participant's muscle strength, with sessions held five days a week over 30 sessions. Blood samples will be collected before and after the program to measure neuroplasticity-related gene expression and histone modification levels. During the study, participants will undergo evaluations before and after the exercise program, including cognitive tests, motor function assessments, spasticity measurements, independence scales, hand function questionnaires, stroke impact assessments, and walking tests. Researchers will analyze genetic and histone changes alongside clinical measures to assess the relationship between epigenetic effects and motor recovery. The study duration covers the baseline and 6-week post-treatment periods to monitor outcomes and safety throughout.
CONDITIONS
Brief Title
Effect of Exercise Gene Expression and Histone Modifications in Patients With Hemiplegia
Who Can Participate
Age: 25Years - 70Years
All Genders
Eligibility Criteria
You may qualify if you...
- Participants applying for rehabilitation after their first stroke
- Stroke caused by ischemia
- Age between 25 and 70 years
- Using medications for at least 1 month and up to 6 months after stroke
You will not qualify if you...
- Stroke caused by reasons other than ischemia
- Having significant neurological diseases other than stroke
- Having systemic or musculoskeletal diseases preventing neurological rehabilitation or participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - 6 weeks
Participants undergo a routine stroke rehabilitation program consisting of active and passive exercises, balance training, walking training, and bicycle ergometry. This program is conducted 5 days a week for a total of 30 sessions to support recovery and neuroplasticity after stroke.
5 visits per week for 6 weeks
Follow-up
Duration - Short-term assessments at baseline and post-treatment
Participants are evaluated before and after the rehabilitation program to assess changes in gene expression, histone acetylation, motor functions, spasticity, daily living activities, and quality of life.
2 visits (pre-treatment and post-treatment assessments)
Trial Site Locations
Total: 1 location
1
Afyonkarahisar Health Sciences University
Afyonkarahisar, Turkey (Türkiye), 0300
Actively Recruiting
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Research Team
H
Hasan Toktaş, Professor
B
Büşra B Kurt, M.D.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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Published Research Related To This Trial
Effects of exercise and pharmacological inhibition of histone deacetylases (HDACs) on epigenetic regulations and gene expressions crucial for neuronal plasticity in the motor cortex.
Hiroshi Maejima, Mika Kitahara, Yasuyuki Takamatsu...
https://pubmed.ncbi.nlm.nih.gov/33152341Effects of aerobic physical exercise on neuroplasticity after stroke: systematic review.
Leandro Goursand Penna, João Pascoa Pinheiro, Sergio Henrique Rodolpho Ramalho...
https://pubmed.ncbi.nlm.nih.gov/34669820