Comparing Ketalar and Dexmedetomidine to Reduce Increased Pain Sensitivity After Remifentanil in Patients Having Laparoscopic Gallbladder Surgery

What this Trial Is About

Researchers are investigating the effects of two complementary treatments, Ketalar and Dexmedetomidine, in preventing increased sensitivity to pain, known as hyperalgesia, following the use of Remifentanil during anesthesia. Remifentanil is an opioid pain reliever with a short half-life that is often used in prolonged anesthesia such as for laparoscopic cholecystectomy, but it can cause increased pain sensitivity after treatment. This study aims to compare how well Ketalar and Dexmedetomidine can reduce this pain sensitivity in patients undergoing this surgical procedure. All patients in the study will receive general anesthesia including Fentanyl, Rocuronium, Isoflurane, and Remifentanil, followed by Morphine and paracetamol during surgery. In addition, patients will be randomly assigned to receive either Ketalar, given as a bolus and continuous infusion during surgery alongside Propofol and Fentanyl, or Dexmedetomidine, given as a bolus over fifteen minutes and continuous infusion during surgery with Propofol and Fentanyl. The study compares these two treatments to assess their effect on pain after Remifentanil use. Participants will be monitored for pain levels and painkiller consumption up to two hours after anesthesia ends. Pain assessments and medication use will be recorded to evaluate how each treatment affects post-operative pain sensitivity. The study runs from April 2024 to August 2026 and includes adult patients undergoing laparoscopic gallbladder removal. Careful monitoring during and after surgery will help researchers understand the impact of these drugs on pain control and opioid-related sensitivity.

Effect of Ketalar or Dexmedetomidine on Increased Sensitivity to Pain Following Treatment With Remifentanil