Laparoscopic Splenectomy and Azygoportal Disconnection to Improve Liver Function in Patients with Cirrhosis and Portal Hypertension

What this Trial Is About

Researchers are evaluating the effect of laparoscopic splenectomy and azygoportal disconnection on improving liver reserve function in patients with liver cirrhosis. The study aims to determine whether this surgical treatment can enhance liver function after surgery and improve the overall prognosis for these patients. The investigation focuses on patients diagnosed with cirrhosis experiencing related complications such as splenomegaly and portal hypertension. Participants undergo laparoscopic splenectomy and azygoportal disconnection performed by the same surgical team. After surgery, a consistent treatment plan including medications and other therapies is followed. Liver reserve function indicators such as TBIL, DBIL, ALB, ALT, INR, PT, Child-Pugh score, ascites, prealbumin, and indocyanine green clearance tests ICG-K, ICG-R 15, ICG-T2 are monitored before surgery and at 3, 6, 12, and 24 months post-surgery to assess changes over time. Throughout the study, patients provide general information and receive nursing care from the same team. Follow-up visits are scheduled to monitor liver function and health status using blood tests and clinical assessments. The primary outcomes focus on liver reserve function measured by ICG clearance tests at multiple time points after surgery, with ongoing observation up to two years. The study participation duration may vary depending on follow-up timing and patient condition.

The Effect of Laparoscopic Splenectomy and Azygoportal Disconnection on Liver Reserve Function for Cirrhosis Patients