The effects of mesenchymal stromal cells and platelet-rich plasma treatments on cutaneous wound healing.
Giselle Ramos-Gonzalez, Lianeth Salazar, Olga Wittig...
https://pubmed.ncbi.nlm.nih.gov/36326886Actively Recruiting
Phase Not Applicable
Age: 20Years - 60Years
All Genders
ID06082531
Therapeutic Effect of Platelet-rich Plasma (PRP) Injection on Knee Osteoarthritis and Periarticular Tissue Injury
Led by Xijing Hospital · Updated on 2025-04-09
300
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the safety and effectiveness of platelet-rich plasma (PRP) injection therapy in repairing osteoarthritis and soft tissue injuries around the knee joint. This exploratory study aims to provide more reliable treatment options for joint injuries by comparing PRP injections to sodium hyaluronate injections in patients with knee osteoarthritis or related cartilage and meniscus injuries. The study is conducted at a single center and includes adults aged 20 to 60 years. Participants receive injections as part of the study, with some receiving PRP injections and others receiving sodium hyaluronate injections into the joint cavity. The trial includes different study arms: preoperative assessment with no intervention, and postoperative evaluations at 6 weeks and 3 months after treatment. The study uses a randomized and double-blind design to compare these treatments. Throughout the study, participants undergo imaging tests including X-rays, CT scans, and MRIs before treatment, 3 weeks after treatment, and 6 months after treatment to assess joint repair progress. Researchers monitor safety and effectiveness based on these imaging outcomes. The total participation duration includes these follow-up assessments, with safety and treatment effects observed over several months.
CONDITIONS
Brief Title
Effect of Platelet-rich Plasma (PRP) Injection on Knee Osteoarthritis
Who Can Participate
Age: 20Years - 60Years
All Genders
Eligibility Criteria
You may qualify if you...
- Participants aged 20 to 60 years old
- Diagnosed with knee osteoarthritis or injuries to cartilage and meniscus around the knee confirmed by clinical and imaging exams
- Preoperative routine tests show no contraindications
- Provided informed consent to participate in the study
You will not qualify if you...
- Significant abnormalities in platelet count or function
- Systemic bloodstream infections
- Prolonged use of anti-inflammatory drugs or systemic corticosteroids
- Skin damage or infection at the injection site
- Presence of tumors or receiving radiotherapy or chemotherapy
- Pregnant or breastfeeding women
- Mental illnesses preventing cooperation with follow-up
- Contraindications for MRI
- Lack of consent from patients or their families
- Other conditions making participation unsuitable
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - Up to 3 months
Participants receive injections of platelet-rich plasma (PRP) or sodium hyaluronate into the knee joint to treat osteoarthritis and periarticular tissue injury.
Visits at pre-operation, 3 weeks after treatment, and 6 months after treatment
Trial Site Locations
Total: 1 location
1
Xijing Hospital
Xi'an, Shannxi, China, 710034
Actively Recruiting
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Research Team
Y
Yanyan Jia
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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Yangming Zhang, Fei Xing, Rong Luo...
https://pubmed.ncbi.nlm.nih.gov/34414200