Study of Eye Irrigation to Reduce Inflammation and Symptoms in Adults with Severe Dry Eye Disease

What this Trial Is About

Researchers are investigating how rinsing certain parts of the eye might reduce inflammation in people with severe dry eye disease. The study is based on the idea that inflammation worsens dry eye symptoms, and by cleaning the ocular surface, symptoms may improve. This trial aims to better understand the role of inflammation and rinsing in managing dry eye. Participants will receive irrigation treatment using a device called Rinsada which rinses the eyelid and parts of the eye surface including the bulbar and palpebral conjunctiva and conjunctival fornix. The study involves a randomized design comparing the treated eye with a control eye that receives no intervention. The primary measurement is the presence of MMP-9, an inflammatory marker, assessed 3 hours after treatment. During the study, participants will undergo assessments including MMP-9 testing, questionnaires on dry eye symptoms like the CDES-Q and Ocular Itch Scale, and keratometry measurements. Researchers will monitor inflammation levels and symptom changes to evaluate the effect of rinsing. The study plans to enroll 150 patients with severe dry eye, with a total of 250 screened. Participation involves regular visits for testing and follow-up assessments.

The Effect of Rinsing on Ocular Inflammation and Symptoms in Patients With Dry Eye Disease