Study of Primary Sjogren Syndrome Related Dry Eye and Its Different Subtypes in Adults

What this Trial Is About

This research aims to better understand primary Sjgrens syndrome related dry eye pSS-DED, a chronic autoimmune condition affecting tear-producing glands and causing dry eye symptoms. The study focuses on patients with different subtypes of dry eye associated with primary Sjgrens syndrome and explores links between affected organs, tear fluid and blood biomarkers, and disease severity and progression. The goal is to develop a new perspective on diagnosis, classification, and treatment of pSS-DED. Participants include dry eye patients visiting a specialized clinic from 2021 to 2028. Those diagnosed with pSS-DED also meet established criteria for primary Sjgrens syndrome. The study observes and collects data without assigning treatments, but one intervention involved is cyclosporine eye drops. Patients are divided into groups based on their dry eye subtype including those with and without primary Sjgrens syndrome. Throughout the study period, from 2021 to 2028, participants undergo regular assessments including evaluation of disease activity using the ESSDAI score, tear production measured by Schirmer test, and tear film stability assessed by break-up time and tear meniscus height. Researchers collect tear fluid and blood samples to analyze biomarkers and monitor ocular symptoms and progression. The study includes patients aged 18 to 80 years and also enrolls healthy volunteers for comparison.

Clinical Cohort Study in Patients With Different Subtypes of Primary Sjogren Syndrome Related Dry Eye