Actively Recruiting
Effect of Sarcopenia and Frailty on Rocuronium Pharmacodynamics in Geriatric Patients
Led by Konya Meram State Hospital · Updated on 2026-05-15
100
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating how sarcopenia and frailty influence the effects of rocuronium, a muscle relaxant used during general anesthesia, in older adults scheduled for elective surgery. This observational study focuses on patients aged 65 to 80 years and aims to understand how these conditions affect rocuronium's pharmacodynamics during surgical procedures. Participants are grouped based on whether they have frailty, sarcopenia, both conditions, or neither. All participants will undergo elective surgery with general anesthesia requiring endotracheal intubation, where rocuronium is used for neuromuscular blockade. Preoperative assessments of frailty and sarcopenia are conducted clinically and with ultrasound. Neuromuscular monitoring is planned throughout anesthesia to observe muscle response. During the study, researchers will measure the onset time of rocuronium, time to muscle recovery after sugammadex administration, and total rocuronium dose used. Participants will be monitored with quantitative neuromuscular tools during surgery. The study also observes recovery times related to muscle function during and after surgery. Participation lasts through the surgical procedure with assessments focused on anesthesia induction and recovery phases.
CONDITIONS
Brief Title
Effect of Sarcopenia and Frailty on Rocuronium Pharmacodynamics in Geriatric Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Scheduled to undergo elective surgery under general anesthesia requiring endotracheal intubation
- Planned use of rocuronium for neuromuscular blockade
- Quantitative neuromuscular monitoring planned during anesthesia
- American Society of Anesthesiologists physical status I-III
- Ability to provide written informed consent
- Completion of preoperative frailty and sarcopenia assessment
You will not qualify if you...
- Emergency surgery
- Known neuromuscular disease
- History of allergy or contraindication to rocuronium, sugammadex
- Severe hepatic insufficiency
- Severe renal insufficiency
- Use of drugs known to significantly affect neuromuscular transmission
- Preoperative mechanical ventilation or intensive care unit admission
- Inability to perform a frailty or sarcopenia assessment
- Patients in whom quantitative neuromuscular monitoring cannot be properly performed
- Refusal to participate in the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 1 week before surgery
Participants undergo preoperative assessments to evaluate frailty and sarcopenia status.
1 visit (in-person)
Duration - Duration of surgery
Participants are monitored during elective surgery under general anesthesia with neuromuscular blockade using rocuronium, including neuromuscular function assessments.
1 visit (in-person, during surgery)
Trial Site Locations
Total: 1 location
1
Betul Kozanhan
Konya, Turkey (Türkiye), 42005
Actively Recruiting
Research Team
B
Betül kozanhan, M.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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