Actively Recruiting
Effect of Silicone Oil on Retinal Electrical Functions in Patients With Rhegmatogenous Retinal Detachment Using Multifocal Electroretinogram
Led by Minia University · Updated on 2026-05-27
50
Participants Needed
1
Research Sites
2 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research investigates the effects of silicone oil on retinal electrical functions in patients with rhegmatogenous retinal detachment (RRD), a leading cause of permanent vision loss. The study focuses on evaluating retinal function after pars plana vitrectomy, a common surgical treatment for RRD. Silicone oil is widely used as a long-term tamponade to restore intraocular volume and support retinal reattachment, but it may cause complications such as emulsification and related eye issues. Participants will undergo vitrectomy surgery followed by implantation of silicone oil as a tamponade. Retinal function will be assessed using multifocal electroretinography (mfERG), which measures electrical responses from different retinal areas, before and after silicone oil removal. The study aims to understand how silicone oil affects retinal function during the months following surgery. During the study, about 50 patients will have their retinal function monitored from 1 to 3 months after vitrectomy using mfERG tests. Researchers will evaluate retinal electrical responses and overall retinal function under light-adapted conditions. This monitoring helps to track changes in retinal health and the impact of silicone oil treatment over time.
CONDITIONS
Brief Title
Effect of Silicon Oil on Retinal Electrical Functions Using Multifocal Electroretinogram
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with primary rhegmatogenous retinal detachment
- Aged between 18 and 70 years
You will not qualify if you...
- History of previous intraocular surgery
- Combined traction-rhegmatogenous retinal detachment
- Presence of ocular diseases such as glaucoma, degenerative myopia, or age-related macular degeneration
- Poor fixation ability
- Uncooperative patients
- Presence of retinopathy
- Emulsified silicone oil or complicated silicone oil removal
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 to 3 months
Participants undergo Pars Plana Vitrectomy with silicone oil tamponade for Rhegmatogenous Retinal Detachment. Multifocal electroretinogram (mfERG) recordings are taken before and after the silicone oil removal to evaluate retinal function.
1 visit for surgery and mfERG recording before silicone oil removal, and 1 follow-up visit for mfERG recording after silicone oil removal
Trial Site Locations
Total: 1 location
1
Faculty of medicine
Minya, Minya Governorate, Egypt, 61111
Actively Recruiting
Research Team
A
Amany Nady Mohammed Mohammed, Resident
A
Amr Abdelrahman, professor
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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