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The Effect of Therapeutic Exercise on Cartilage Morphology and Physical Function for Individuals at High Risk of Knee Osteoarthritis
Led by Jordan University of Science and Technology · Updated on 2026-05-12
50
Participants Needed
2
Research Sites
404 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This randomized controlled trial aims to evaluate the efficacy of progressive resistance exercises (PRE) versus aerobic exercises on cartilage morphology and physical function in patients with degenerative meniscus tears. 45 participants, aged 35-55, will be randomly assigned to one of three groups: PRE, aerobic exercise, or control (standard of care physical and medical therapy). The study will utilize MRI T2 mapping to assess changes in cartilage composition and patient-reported and performance-based measures to evaluate clinical outcomes. This pilot study will also determine the feasibility and issues related to recruitment and retention for a larger trial.
CONDITIONS
Official Title
The Effect of Therapeutic Exercise on Cartilage Morphology and Physical Function for Individuals at High Risk of Knee Osteoarthritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be between 35 and 55 years old
- Have symptomatic degenerative medial meniscus tear with medial knee pain
- Have medial joint line tenderness
- Experience pain and limited motion when performing a full squat
- Show increased intra-meniscal signal on at least 2 consecutive MRI slices
- Have clearance from personal physician to participate in exercise program
You will not qualify if you...
- Have radiographic evidence of osteoarthritis with Kellgren-Lawrence grade 2 or higher
- Have a repairable meniscus injury (longitudinal tear in outer 1/3 of meniscus)
- Have a meniscus injury requiring meniscectomy (locked knee)
- Have prior or current ligament injury or surgery in involved knee
- Have prior or current injury or surgery in opposite knee
- Have pathological ligamentous laxity in the knee
- Have an inflammatory arthritic condition
- Have any injury or condition affecting lower extremities that impacts walking ability
- Are pregnant at time of enrollment (if female)
- Had prior surgery for an aneurysm or medical illness affecting fitness or exercise ability
- Have contraindications to MRI
- Had surgery within past two months
- Have a cardiac pacemaker
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
King Abdullah University Hospital
Ar Ramtha, Jordan
Actively Recruiting
2
Jordan University of Science and Technology
Irbid, Jordan
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How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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