Comparative Analysis of Ventilation Distribution in Intensive Care Using Electrical Impedance Tomography: Mandatory Minute Ventilation Versus Synchronized Intermittent Mandatory Ventilation

What this Trial Is About

This research aims to compare two common ventilation modes, Mandatory Minute Ventilation (MMV) and Synchronized Intermittent Mandatory Ventilation (SIMV), in adult patients who are mechanically ventilated and hemodynamically stable in an intensive care unit. MMV combines features of SIMV and Pressure Support Ventilation to ensure a preset minute ventilation, while SIMV delivers a fixed number of breaths synchronized with spontaneous breathing. Electrical Impedance Tomography (EIT), a non-invasive imaging method, will be used to monitor lung ventilation and perfusion in real time. Participants will receive both SIMV and MMV modes for 12 hours each, with a randomized order and a one-hour washout period in between to reduce carry-over effects. Monitoring will include EIT to assess lung ventilation distribution and measurements of gas exchange parameters such as PO2/FiO2 ratio, PaCO2, and EtCO2. No investigational treatments are administered; patients will be observed under standard ventilation care. During the study, patients will be closely monitored using EIT and standard respiratory measurements to evaluate ventilation effectiveness under each mode. The primary measure is the change in regional lung ventilation within one hour after starting each mode. Secondary measures include oxygenation indexes recorded in the same timeframe. The study lasts for the duration of the two 12-hour ventilation periods plus washout, focusing on adults who meet specific stability criteria.

Effectiveness of Ventilation Modes in Intensive Care: A Comparison of Mandatory Minute Ventilation and Synchronized Intermittant Mandatory Ventilation Using Bioelectrical Impedance Tomography