Actively Recruiting
Abnormalities of Plasma Willebrand Factor Activity Induced by Bothrops Snakebites Endemic to Martinique and French Guyana
Led by University Hospital Center of Martinique · Updated on 2024-09-26
30
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University Hospital Center of Martinique
Lead Sponsor
U
University Hospital, Lille
Collaborating Sponsor
AI-Summary
What this Trial Is About
Snakebites from Bothrops species are a significant health concern in French Guiana and Martinique, with envenomation causing severe local and systemic effects. This research aims to explore the role of plasma Willebrand factor activity and endothelial activation in patients bitten by Bothrops snakes in these regions. The study investigates how venom from different Bothrops species affects blood clotting and inflammation, potentially explaining distinct clinical outcomes like bleeding or thrombosis. Understanding these mechanisms could lead to more personalized treatment approaches for snakebite victims. Participants include patients with confirmed Bothrops snakebites from French Guiana and Martinique, divided into two groups of 15 each. Blood samples will be collected for research analysis alongside routine care, focusing on Willebrand factor activity before and after anti-venom treatment. The study does not involve new treatments but monitors biological markers related to coagulation and endothelial function to understand venom effects better. During the study, patients will have additional blood drawn at hospital admission and on days 1 and 8 to measure plasma Willebrand factor activity. Researchers will assess coagulation status and related biological changes while recording clinical signs of envenomation. The study is observational, with no experimental interventions, and participants are followed up during their hospital stay to gather data on venom effects and recovery. Total participation duration varies depending on clinical course but includes key blood sampling points within the first week.
CONDITIONS
Brief Title
Effects of Bothrops Spp. Snake Envenomation on Willebrand Factor Activity in Martinique and French Guiana
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men or Women, at least 18 years old
- Admitted to the Emergency Department of Martinique University Hospital or Cayenne University Hospital
- Victim of a confirmed Bothrops snake bite in Martinique or French Guiana, identified by the patient or their entourage
- Confirmed diagnosis of stage III or IV envenomation with specified local and general symptoms
- Able to understand information about the research and give verbal consent
- Able to provide written informed consent for participation
- Affiliated with the general social security system
You will not qualify if you...
- Pregnant or breastfeeding women
- People previously treated for snakebite with Bothrofav® or Antivipmyn-tri® anti-venom
- Known bleeding or clotting disorders such as haemophilia, vitamin K deficiency, liver insufficiency, circulating anticoagulants
- Presence of disseminated intravascular coagulation (DIC)
- Constitutional or acquired Von Willebrand disease
- Constitutional or acquired thrombopathies
- Idiopathic thrombocytopenic purpura
- Persons under legal protection or deprived of liberty
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 9 days
Participants who undergo routine care for Bothrops snake envenomation are observed with additional blood samples collected for research analysis.
3 visits (Day 0, Day 1, and Day 8)
Trial Site Locations
Total: 1 location
1
University Hospital Center of Martinique
Fort-de-France, Martinique, Martinique, 97200
Actively Recruiting
Research Team
S
SEBASTIEN CAVALINI
C
CORINE CARPIN
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here