Study of Willebrand Factor Changes After Bothrops Snake Bites in Martinique and French Guiana Observing Effects on Blood Clotting and Bleeding in Adults

What this Trial Is About

Snakebites from Bothrops species are a significant health concern in French Guiana and Martinique, with envenomation causing severe local and systemic effects. This research aims to explore the role of plasma Willebrand factor activity and endothelial activation in patients bitten by Bothrops snakes in these regions. The study investigates how venom from different Bothrops species affects blood clotting and inflammation, potentially explaining distinct clinical outcomes like bleeding or thrombosis. Understanding these mechanisms could lead to more personalized treatment approaches for snakebite victims. Participants include patients with confirmed Bothrops snakebites from French Guiana and Martinique, divided into two groups of 15 each. Blood samples will be collected for research analysis alongside routine care, focusing on Willebrand factor activity before and after anti-venom treatment. The study does not involve new treatments but monitors biological markers related to coagulation and endothelial function to understand venom effects better. During the study, patients will have additional blood drawn at hospital admission and on days 1 and 8 to measure plasma Willebrand factor activity. Researchers will assess coagulation status and related biological changes while recording clinical signs of envenomation. The study is observational, with no experimental interventions, and participants are followed up during their hospital stay to gather data on venom effects and recovery. Total participation duration varies depending on clinical course but includes key blood sampling points within the first week.

Effects of Bothrops Spp. Snake Envenomation on Willebrand Factor Activity in Martinique and French Guiana