Actively Recruiting
Effects of High-Resistance Inspiratory Muscle Strength Training on Cardiorenal and Vascular Function in Youth and Young Adults With Type 2 Diabetes
Led by Seattle Children's Hospital · Updated on 2025-06-13
90
Participants Needed
2
Research Sites
43 weeks
Total Duration
On this page
Sponsors
S
Seattle Children's Hospital
Lead Sponsor
U
University of Washington
Collaborating Sponsor
AI-Summary
What this Trial Is About
High-resistance, short-duration inspiratory muscle strength training (IMST) is a novel lifestyle intervention involving 30 inhalations against a resistive load which requires only \~5 min/day and is thus ideal for youth with T2D (Y-T2D). Investigators seek to 1: assess changes in casual and 24-hr SBP, endothelial function, and arterial stiffness after 3 months of IMST vs. sham training in Y-T2D, 2: Define changes in eGFR andalbuminuria after 3 months of IMST vs. sham in Y-T2D, 3: Interrogate mechanisms of IMST by translational assessments of NO bioavailability, endothelial NO synthase (eNOS) activation, and ROS/oxidative stress, and determine the role of circulating factors.
CONDITIONS
Official Title
Effects of High-Resistance Inspiratory Muscle Strength Training on Cardiorenal and Vascular Function in Youth and Young Adults With Type 2 Diabetes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 14 to 40 years
- Diagnosed with type 2 diabetes for at least one year
- HbA1C less than 12%
You will not qualify if you...
- Type 2 diabetes duration more than 18 years
- Estimated glomerular filtration rate (eGFR) less than 60 ml/min/1.73m2
- Albumin-to-creatinine ratio (ACR) greater than 2200 mg/g
- Blood pressure greater than 160/100 mm Hg
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Seattle Children's Hospital
Seattle, Washington, United States, 98102
Actively Recruiting
2
University of Washington Medicine Diabetes Institute
Seattle, Washington, United States, 98109
Not Yet Recruiting
Research Team
K
Kalie Tommerdahl, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here