Observational Study on Intracoronary Adenosine Use for Coronary Flow Reserve and Microcirculatory Resistance in Angina Patients

What this Trial Is About

This study focuses on people with angina to explore the use of intracoronary adenosine during tests that measure coronary flow reserve CFR and index of microcirculatory resistance IMR. Researchers aim to understand how repeatable these measurements are when adenosine is given and to evaluate how coronary waveform signals relate to ischemia defined by fractional flow reserve FFR and CFR. The study also looks at how well FFR, CFR, and IMR predict major cardiovascular problems over three years. Participants will undergo repeated intracoronary adenosine administration while CFR and IMR measurements are taken in a catheterization lab. This procedure helps assess heart blood flow and resistance in small vessels. The study involves monitoring these measurements during the procedure, followed by clinical follow-up over three years to track cardiovascular outcomes. During the study, participants will have FFR, CFR, and IMR assessments in the catheterization laboratory. The main outcome measured is the repeatability of CFR and IMR values within 10 minutes. Researchers will also follow participants for three years to observe major adverse cardiovascular events. This approach helps understand the reliability of the tests and their ability to predict future heart problems.

A Study of Pressure Waveform Analysis in Coronary Artery-II