Actively Recruiting
Elderly Patients Undergoing Surgery During Perioperative Period: a Prospective Cohort Study
Led by Second Affiliated Hospital of Wenzhou Medical University · Updated on 2026-04-01
1200
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating postoperative complications and delirium in elderly patients undergoing surgery. This study aims to identify risk factors and understand the causes of postoperative delirium and other complications in patients aged 65 and older. The goal is to develop a risk prediction model to improve care and outcomes for elderly surgical patients. The study includes two groups: elderly patients undergoing surgery and elderly non-surgical subjects. For surgical patients, questionnaires and scales assessing cognitive function, sleep quality, and quality of life are collected before surgery, daily for the first week after surgery, at 30 days, and at one year post-operation. Biological samples such as blood and cerebrospinal fluid are collected during surgery. Non-surgical participants provide basic information along with cognitive, sleep, and quality of life assessments. Participants are monitored through various assessments including cognitive scales, sleep questionnaires, and quality of life measurements at multiple time points before and after surgery. Researchers track the incidence, type, severity, and duration of postoperative delirium within the first week after surgery. Additional outcomes include neurocognitive dysfunction, pain levels, anxiety and depression scores, daily living activities, frailty, mortality, hospital stay length, days spent at home after surgery, and economic factors. The study follows participants for up to one year to gather comprehensive data on recovery and complications.
CONDITIONS
Brief Title
Elderly Patients Undergoing Surgery During Perioperative Period
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Surgical patients aged 65 or above
- Non-surgical subjects aged 65 or above
- Agree to participate in the study and sign the informed consent form
You will not qualify if you...
- Refused to participate in the study
AI-Screening
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Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Preoperative period
For surgical participants, baseline assessments including questionnaires and scales measuring cognitive function, sleep quality, and quality of life are collected before surgery. For non-surgical participants, cognitive scales, sleep scales, and quality of life questionnaires are collected.
1 baseline visit (in-person)
Duration - Hospitalization, approximately 7 days
Surgical participants undergo surgery during which biological samples such as blood and cerebrospinal fluid are collected. Postoperative assessments for delirium, acute pain, and hospital stay occur during hospitalization.
Daily visits during hospital stay (in-person) for up to 7 days
Duration - Up to 1 year after surgery
Participants are followed up to assess postoperative neurocognitive function, sleep quality, quality of life, anxiety and depression, frailty, activity of daily living, mortality, and economic indicators at multiple time points after surgery.
Visits at 5 days, 1 month, 6 months, and 1 year post-operation (in-person or remote)
Duration - Up to 1 year
Non-surgical participants undergo periodic assessments of cognitive function, sleep quality, and quality of life during the study period.
Periodic visits depending on cohort assignment
Trial Site Locations
Total: 1 location
1
The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
Wenzhou, Zhejiang, China, 325000
Actively Recruiting
Research Team
T
Ting Li MD. PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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