Actively Recruiting
Erector Spinae Plane Block Versus Modified Thoracoabdominal Nerve Block for Pain Control After Laparoscopic Cholecystectomy
Led by Alexandria University · Updated on 2026-06-03
50
Participants Needed
1
Research Sites
12 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are comparing two regional anesthesia techniques, the erector spinae plane block (ESPB) and the modified thoracoabdominal nerve block through the perichondrial approach (M-TAPA), to study their effectiveness in managing pain after laparoscopic cholecystectomy (LC). LC is a common minimally invasive surgery for gallbladder disease that usually causes less pain than open surgery, but many patients still experience moderate to severe pain after the procedure. The study aims to find out which block provides better pain relief by targeting different nerves and areas of the abdomen. Participants will be randomly assigned to receive either bilateral ESPB or bilateral M-TAPA during surgery under general anesthesia. Both groups will receive 20 ml of 0.25% bupivacaine injected under ultrasound guidance at specific anatomical sites: ESPB targets the erector spinae muscle near the spine, while M-TAPA targets the thoracoabdominal nerves beneath the costal cartilage. After surgery, all patients will receive standard pain medications, and rescue analgesics will be given if needed. During the study, patients will be monitored closely for pain levels, time until first pain medication is requested, total opioid use, patient satisfaction, quality of recovery, and any complications or side effects. Monitoring includes vital signs, pain scores, nausea, and vomiting assessments. The primary outcome is the time to first analgesic request within the first postoperative day, with additional assessments up to five days after surgery. The study lasts from the start of surgery through early postoperative recovery, focusing on improving pain control and patient comfort.
CONDITIONS
Brief Title
Erector Spina Plane Block Versus Modified Thoracoabdominal Nerve Block After Laparoscopic Cholecystectomy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 30 and 65 years
- American Society of Anesthesiologists physical status I to III
- Body mass index between 18 and 35 kg/m2
You will not qualify if you...
- Patient refusal to participate
- Allergy to local anaesthetic agents
- Skin infection at the injection site
- Coagulopathy
- Diabetes mellitus
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Surgery day
Participants receive either bilateral Erector Spinae Plane Block (ESPB) or bilateral Modified Thoracoabdominal Nerve Block (M-TAPA) after induction of general anesthesia prior to laparoscopic cholecystectomy.
1 visit (in-person, surgery and block administration)
Duration - 5 days
Participants are monitored for pain control, analgesic consumption, nausea, and recovery quality in the first 24 hours after surgery, with additional assessment of complications or adverse events up to 5 days post-surgery.
Daily visits for up to 5 days
Trial Site Locations
Total: 1 location
1
Alexandria University
Alexandria, Egypt
Actively Recruiting
Research Team
S
sarah m elgamal, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here