Actively Recruiting

Phase Not Applicable
Age: 30Years - 65Years
All Genders
ID07624058

Erector Spinae Plane Block Versus Modified Thoracoabdominal Nerve Block for Pain Control After Laparoscopic Cholecystectomy

Led by Alexandria University · Updated on 2026-06-03

50

Participants Needed

1

Research Sites

12 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are comparing two regional anesthesia techniques, the erector spinae plane block (ESPB) and the modified thoracoabdominal nerve block through the perichondrial approach (M-TAPA), to study their effectiveness in managing pain after laparoscopic cholecystectomy (LC). LC is a common minimally invasive surgery for gallbladder disease that usually causes less pain than open surgery, but many patients still experience moderate to severe pain after the procedure. The study aims to find out which block provides better pain relief by targeting different nerves and areas of the abdomen. Participants will be randomly assigned to receive either bilateral ESPB or bilateral M-TAPA during surgery under general anesthesia. Both groups will receive 20 ml of 0.25% bupivacaine injected under ultrasound guidance at specific anatomical sites: ESPB targets the erector spinae muscle near the spine, while M-TAPA targets the thoracoabdominal nerves beneath the costal cartilage. After surgery, all patients will receive standard pain medications, and rescue analgesics will be given if needed. During the study, patients will be monitored closely for pain levels, time until first pain medication is requested, total opioid use, patient satisfaction, quality of recovery, and any complications or side effects. Monitoring includes vital signs, pain scores, nausea, and vomiting assessments. The primary outcome is the time to first analgesic request within the first postoperative day, with additional assessments up to five days after surgery. The study lasts from the start of surgery through early postoperative recovery, focusing on improving pain control and patient comfort.

CONDITIONS

Brief Title

Erector Spina Plane Block Versus Modified Thoracoabdominal Nerve Block After Laparoscopic Cholecystectomy

Who Can Participate

Age: 30Years - 65Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age between 30 and 65 years
  • American Society of Anesthesiologists physical status I to III
  • Body mass index between 18 and 35 kg/m2
Not Eligible

You will not qualify if you...

  • Patient refusal to participate
  • Allergy to local anaesthetic agents
  • Skin infection at the injection site
  • Coagulopathy
  • Diabetes mellitus

AI-Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - Surgery day

Participants receive either bilateral Erector Spinae Plane Block (ESPB) or bilateral Modified Thoracoabdominal Nerve Block (M-TAPA) after induction of general anesthesia prior to laparoscopic cholecystectomy.

1 visit (in-person, surgery and block administration)

Post-operative Follow-up

Duration - 5 days

Participants are monitored for pain control, analgesic consumption, nausea, and recovery quality in the first 24 hours after surgery, with additional assessment of complications or adverse events up to 5 days post-surgery.

Daily visits for up to 5 days

Trial Site Locations

Total: 1 location

1

Alexandria University

Alexandria, Egypt

Actively Recruiting

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Research Team

S

sarah m elgamal, MD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

TRIPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

OTHER

Number of Arms

2

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