Actively Recruiting
Esketamine Nasal Spray in Real-World Settings in Treatment-Resistant Depression
Led by Riccardo Guglielmo · Updated on 2026-03-31
100
Participants Needed
5
Research Sites
404 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This observational study investigates the use of Esketamine Intranasal Spray in patients with Treatment-Resistant Depression in Real-World Settings. The study aims to evaluate the clinical outcomes, including efficacy and safety, of esketamine treatment. It also explores predictors of treatment response, focusing on biological pathways such as genetics, neuroimaging, and psychophysical measures. Additionally, the study examines how esketamine impacts patients' life functioning, including social and occupational aspects. The goal is to better understand who benefits most from esketamine and how it affects daily life, to improve personalized care for patients with difficult-to-treat depression.
CONDITIONS
Official Title
Esketamine Nasal Spray in Real-World Settings in Treatment-Resistant Depression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 74 years
- Diagnosis of a major depressive episode according to DSM-5
- Failure to respond to at least two prior antidepressant treatments
- Current treatment with an SSRI or SNRI suitable for esketamine nasal spray
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 5 locations
1
Ospedale Policlinico San Martino
Genova, Ge, Italy, 16132
Actively Recruiting
2
Csm Dds 8
Genova, Ge, Italy, 16158
Actively Recruiting
3
Università di Chieti
Chieti, Italy, 66100
Actively Recruiting
4
ASST Fatebenefratelli Sacco
Milan, Italy, 20157
Actively Recruiting
5
ASST Pavia
Pavia, Italy, 27100
Actively Recruiting
Research Team
R
Riccardo Guglielmo, MD
CONTACT
E
Elisa Cavanna, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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