Actively Recruiting
To Evaluate Mucosal and Systematic Immune Response to Acute Respiratory Tract Infections of South African Children
Led by Desmond Tutu TB Centre · Updated on 2025-03-30
250
Participants Needed
2
Research Sites
53 weeks
Total Duration
On this page
Sponsors
D
Desmond Tutu TB Centre
Lead Sponsor
E
European Union
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to answer a few questions about respiratory tract infections in South African children: 1. How do children with COVID-19 and other respiratory (chest, throat, ear or nose) germs show symptoms? What signs should be looked for, and which children are more likely to get seriously ill? Are there any new germs that haven't been discovered yet? Can immune cells in saliva predict which children will get more severe disease? 2. The body's immune response (soldier- cells) in blood and saliva (spit) will be studied. 3. What is the short-term effect of COVID-19 and other respiratory viruses/ germs on the breathing (lung function) of children? 4. What is the impact of respiratory germs on the quality of life in children and their families? The investigators aim to recruit a minimum of 250 children with respiratory pathogens.
CONDITIONS
Official Title
To Evaluate Mucosal and Systematic Immune Response to Acute Respiratory Tract Infections of South African Children
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children aged 0-13 years with acute respiratory tract infections presenting to Tygerberg Hospital (TBH) in Cape Town, South Africa, for routine care
You will not qualify if you...
- Admitted for less than 72 hours
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Desmond Tutu TB Centre, Tygerberg Hospital
Cape Town, Western Cape, South Africa, 7505
Actively Recruiting
2
Desmond Tutu TB Centre
Cape Town, Western Cape, South Africa, 7505
Actively Recruiting
Research Team
M
Margaret van Niekerk, Masters (Human Nutrition)
CONTACT
M
Michaile Mackriel, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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