Study of Respiratory Infections and Their Long-Term Effects in Newborns in Colombia and Panama

What this Trial Is About

Researchers are studying respiratory tract infections RTIs in young children from birth to five years old in Colombia and Panam. The study aims to understand how often these infections occur, which viruses or bacteria cause them, and why some children experience more severe illness. It also explores how early infections and vaccinations affect the immune system and long-term respiratory health. This observational study follows newborns over time to learn about the causes and effects of RTIs in community settings, especially where data is limited. The study involves active monitoring of children from birth until age five. Families are contacted twice weekly via a phone app or calls to track symptoms. If a child becomes ill, they attend in-person visits where nasal and blood samples are collected to identify pathogens and study immune responses. Routine check-ups occur every six months during the first two years, then continue biannually until age five to observe long-term outcomes. No experimental treatments are given. Participants parents or guardians provide informed consent and help with ongoing data and sample collection. The research team measures the incidence and severity of infections, including hospitalizations and intensive care needs, and examines bacterial loads and immune system reactions. This long-term follow-up helps understand RTIs impact on childrens health and supports future prevention and treatment efforts. The study began in May 2024 and will continue until children reach five years old.

Respiratory Infections in Young Children