Actively Recruiting

Phase Not Applicable
Age: 18Years - 75Years
All Genders
Healthy Volunteers
ID07560280

Evaluation Criteria, Diagnostic Criteria, Surgical Indications, and Establishment of Surgical Standards for Cerebral Tinnitus Syndrome Caused by Internal Jugular Vein Stenosis

Led by Beijing Shijitan Hospital, Capital Medical University · Updated on 2026-05-01

369

Participants Needed

1

Research Sites

52 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are investigating "Cerebral Tinnitus Syndrome," a condition marked by the perception of internal head sounds along with symptoms like hearing loss, headaches, blurred vision, and sleep disturbances. This syndrome is linked to narrowing of the internal jugular veins, which disrupts brain blood flow and waste removal. The study aims to develop standardized criteria for diagnosis and surgery to better treat this condition, which currently lacks effective therapies and significantly impacts patients' quality of life. The trial involves a surgical procedure called internal jugular vein decompression to relieve vein narrowing caused by bony or soft tissue compression. The surgery includes bone removal and soft tissue release around the vein, followed by increasing blood pressure during surgery to improve blood flow. Researchers will perform this procedure on 107 patients, using strict evaluation and surgical standards to improve treatment outcomes and create clinical guidelines. Participants will undergo symptom assessments, imaging tests, and multidisciplinary evaluations before surgery. Postoperative follow-ups at 3 and 12 months will monitor improvements in tinnitus and other symptoms, vein shape, and blood flow, as well as safety outcomes. The study will also build a database and evaluation scale for cerebral tinnitus, aiming to improve diagnosis, treatment, and patient quality of life over the study period.

CONDITIONS

Brief Title

Evaluation Criteria, Diagnostic Criteria, Surgical Indications, and Establishment of Surgical Standards for "Cerebral Tinnitus Syndrome" Caused by Internal Jugular Vein Stenosis.

Who Can Participate

Age: 18Years - 75Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Age between 18 and 75 years, with no gender restriction
  • Presence of one or more symptoms associated with "Cerebral Tinnitus Syndrome" lasting at least 3 months
  • Preliminary exclusion of other known causes of cerebral tinnitus with suspected internal jugular vein stenosis
  • Imaging shows significant narrowing of the internal jugular vein (stenosis degree ≥50%)
  • Patient has provided informed consent and agrees to participate
Not Eligible

You will not qualify if you...

  • History of cranial surgery or diagnosed intracranial space-occupying lesions
  • Severe heart, liver, or kidney failure, or other major systemic diseases
  • Surgery or intervention affecting jugular venous flow within the last 6 months
  • History of psychiatric disorders or cognitive impairment preventing study completion
  • Pregnant or breastfeeding women

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Surgery

Duration - Day of surgery

Participants undergo internal jugular vein decompression surgery to relieve stenosis or compression of the vein, aiming to restore normal cerebral venous outflow and alleviate symptoms of cerebral tinnitus syndrome.

1 surgical visit (in-person)

Post-operative Follow-up

Duration - Up to 12 months postoperatively

Participants are monitored after surgery to assess improvement in cerebral tinnitus and other symptoms, recovery of vein morphology and blood flow, and safety outcomes.

Visits at 3 months and 12 months postoperatively (in-person)

Trial Site Locations

Total: 1 location

1

Beijing Shijitan Hospital, Capital Medical University

Beijing, Beijing Municipality, China, 100038

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Research Team

Z

Zhiqiang Hu

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

1

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