Internal jugular vein stenosis associated with elongated styloid process: five case reports and literature review.
Min Li, Yuan Sun, Chong Ching Chan...
https://pubmed.ncbi.nlm.nih.gov/31164090Actively Recruiting
Led by Beijing Shijitan Hospital, Capital Medical University · Updated on 2026-05-01
369
Participants Needed
1
Research Sites
52 weeks
Total Duration
Researchers are investigating "Cerebral Tinnitus Syndrome," a condition marked by the perception of internal head sounds along with symptoms like hearing loss, headaches, blurred vision, and sleep disturbances. This syndrome is linked to narrowing of the internal jugular veins, which disrupts brain blood flow and waste removal. The study aims to develop standardized criteria for diagnosis and surgery to better treat this condition, which currently lacks effective therapies and significantly impacts patients' quality of life. The trial involves a surgical procedure called internal jugular vein decompression to relieve vein narrowing caused by bony or soft tissue compression. The surgery includes bone removal and soft tissue release around the vein, followed by increasing blood pressure during surgery to improve blood flow. Researchers will perform this procedure on 107 patients, using strict evaluation and surgical standards to improve treatment outcomes and create clinical guidelines. Participants will undergo symptom assessments, imaging tests, and multidisciplinary evaluations before surgery. Postoperative follow-ups at 3 and 12 months will monitor improvements in tinnitus and other symptoms, vein shape, and blood flow, as well as safety outcomes. The study will also build a database and evaluation scale for cerebral tinnitus, aiming to improve diagnosis, treatment, and patient quality of life over the study period.
CONDITIONS
Evaluation Criteria, Diagnostic Criteria, Surgical Indications, and Establishment of Surgical Standards for "Cerebral Tinnitus Syndrome" Caused by Internal Jugular Vein Stenosis.
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Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Day of surgery
Participants undergo internal jugular vein decompression surgery to relieve stenosis or compression of the vein, aiming to restore normal cerebral venous outflow and alleviate symptoms of cerebral tinnitus syndrome.
1 surgical visit (in-person)
Duration - Up to 12 months postoperatively
Participants are monitored after surgery to assess improvement in cerebral tinnitus and other symptoms, recovery of vein morphology and blood flow, and safety outcomes.
Visits at 3 months and 12 months postoperatively (in-person)
Total: 1 location
1
Beijing Shijitan Hospital, Capital Medical University
Beijing, Beijing Municipality, China, 100038
Actively Recruiting
Z
Zhiqiang Hu
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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Min Li, Yuan Sun, Chong Ching Chan...
https://pubmed.ncbi.nlm.nih.gov/31164090