Study to Evaluate a New Contrast-Free Dynamic CT Scan Method for Lung Imaging

What this Trial Is About

Researchers are evaluating a new computed tomography CT lung perfusion imaging method called X-ray Pulsatility Index XPI using dynamic CT scans. This method differs from conventional static CT scans and aims to determine if it provides more detailed information about lung perfusion compared to the standard of care CT imaging. The study is a phase 2 interventional trial focused on diagnostic evaluation. Participants will undergo a dynamic, contrast-free chest CT scan lasting approximately 30 minutes. The study involves collecting high frame rate imaging data to map lung perfusion and assess the XPI. This imaging approach is being studied as an alternative to standard CT scans without using contrast agents. During the trial, participants will have a single 30-minute chest CT scan. Researchers will measure various aspects of the XPI, including its presence, magnitude, and spatial distribution in the lungs. The study will monitor imaging results and safety throughout participation, which lasts until study completion in December 2026.

Evaluation of CT-XPI