Randomized Double-Blind Study of Skal Pro Powder to Improve Symptoms and Quality of Life in Adults With Irritable Bowel Syndrome

What this Trial Is About

This research aims to evaluate the effectiveness of Skal Pro powder in reducing symptoms, improving stool consistency, enhancing quality of life, and addressing psychological distress in people with irritable bowel syndrome IBS. IBS is linked to disruptions in the gut-brain axis and changes in gut bacteria, but the best probiotic strains for treatment are not yet clear. The study focuses on the effects of Skal Pro, containing Lactobacillus plantarum 299v and galactooligosaccharides GOS, specifically within the Malaysian population. Participants will be randomly assigned to receive either Skal Pro powder or a placebo powder that looks and tastes the same. The Skal Pro sachet contains 10 billion CFU of freeze-dried Lactobacillus plantarum 299v and GOS. Each participant will take one sachet daily during the study, which will last for 4 weeks. During the study, participants will track and report their IBS symptoms, stool consistency and frequency, abdominal bloating, quality of life, and psychological factors using questionnaires and daily diaries. These assessments will occur at the start, during Week 1, Week 2, and at the end of Week 4. The main outcome measured is the change in IBS symptom severity. The study includes safety monitoring and will evaluate changes in several secondary outcomes related to gastrointestinal and psychological health.

Evaluation of Efficacy of Skål Pro Powder on Symptoms of Irritable Bowel Syndrome