Actively Recruiting
Examining the Impact of Exercise Training on Vascular Dysfunction in Individuals With Mental Health Disorders - Study 1
Led by Virginia Commonwealth University · Updated on 2026-05-05
720
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research investigates how oxidants, substances in the blood that may harm blood vessels, affect blood vessel function in healthy people and those with mental health disorders like posttraumatic stress disorder (PTSD) and generalized anxiety disorder (GAD). The goal is to better understand vascular health in these groups and the role of oxidants. The study is an interventional trial with randomized and quadruple masking design. Participants take part in three separate sessions over about two weeks at the Exercise Physiology Research Laboratory. In the first visit, they become familiar with the study equipment and procedures, have body measurements taken, forearm and calf strength tested, and provide a blood sample. In visits two and three, lasting 2-3 hours each, they receive either antioxidant pills or placebo pills in a randomized order to assess how these affect blood vessel health. During the study, researchers measure arm and leg vascular function at rest and in response to exercise using tests such as flow-mediated dilation, passive leg movement, and handgrip exercise tests. These assessments occur from baseline through the final visit over roughly two weeks. The study monitors the effects of antioxidant versus placebo intake on blood vessel function to understand vascular health in individuals with and without mental health disorders.
CONDITIONS
Brief Title
Examining the Impact of Exercise Training on Vascular Dysfunction in Individuals With Mental Health Disorders - Study 1
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Apparently healthy and free of cardiovascular, pulmonary, or metabolic disease
- For PTSD group, a score of 2 33 on PCL-5 checklist
- For GAD group, a score of 2 10 on the GAD-7 self-report scale and C 33 on the PCL-5 checklist
- For Healthy Control group, a score of C 10 on the GAD-7 self-report scale and C 33 on the PCL-5 checklist
- Age between 18 and 35 years
You will not qualify if you...
- Taking medications that could influence cardiovascular function
- Current smokers or recent quitters
- Illicit drug use or excessive alcohol consumption
- Pregnant women
- Significant calorie restriction or vitamin/mineral deficiencies
- Limited English proficiency
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 2 weeks
Participants attend three testing sessions on separate days to assess vascular health and ingest either antioxidant or placebo pills in a randomized crossover design.
3 visits (in-person)
Trial Site Locations
Total: 1 location
1
Virginia Commonwealth University
Richmond, Virginia, United States, 23298
Actively Recruiting
Research Team
R
Ryan Garten, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here