Actively Recruiting
Examining the Impact of Exercise Training on Vascular Dysfunction in Individuals With Mental Health Disorders - Study 2
Led by Virginia Commonwealth University · Updated on 2025-11-17
360
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to study how different exercise training programs affect blood vessel function in healthy adults and those with mental health disorders such as posttraumatic stress disorder (PTSD) and generalized anxiety disorder (GAD). The study focuses on understanding vascular dysfunction related to these conditions by comparing exercise impacts in these groups. The study involves seven visits over about 14 weeks at the Exercise Physiology Research Laboratory. Initial visits include familiarization with study equipment, body measurements, strength tests, and blood draws. Participants receive antioxidant or placebo pills on two separate visits to evaluate oxidants' effects on blood vessels. They undergo a 10-week exercise training program varying by intensity and frequency: moderate intensity normal volume, high intensity normal volume, or moderate intensity high volume treadmill running. Participants will complete various vascular health tests, including flow mediated dilation, passive leg movement, and handgrip exercise tests, before and after exercise training. The study includes monitoring body composition, strength, and blood samples. Researchers track changes in arm and leg vascular function from baseline through the final visit. The entire process takes about 14 weeks, with multiple testing days to assess endurance, strength, and vascular response.
CONDITIONS
Brief Title
Examining the Impact of Exercise Training on Vascular Dysfunction in Individuals With Mental Health Disorders - Study 2
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Apparently healthy and free of overt cardiovascular, pulmonary, or metabolic disease
- For PTSD group, a score of 6 33 on PCL-5 checklist
- For GAD group, a score of 6 10 on the GAD-7 self-report scale and < 33 on the PCL-5 checklist
- For Healthy Control group, a score of 4 10 on the GAD-7 self-report scale and < 33 on the PCL-5 checklist
You will not qualify if you...
- Taking medications that could influence cardiovascular function
- Current smokers who have recently quit smoking
- Illicit drug use or excessive alcohol consumption
- Pregnant women
- Significant calorie restriction or vitamin/mineral deficiencies
- Limited English proficiency
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - Up to 14 weeks
Participants are screened for eligibility to participate in the trial.
5 testing sessions on separate days
Duration - 10 weeks
Participants complete 10 weeks of exercise training with one of three treadmill running programs varying in intensity and frequency.
Exercise training 3-5 days per week
Duration - Throughout the study period up to about 14 weeks
Participants complete multiple testing visits to assess vascular function including blood vessel health tests with antioxidant or placebo pills and endurance or strength tests before and after exercise training.
7 testing visits (Visits 1, 2, 3, 4, 5, 6, and 7) with variable durations
Trial Site Locations
Total: 1 location
1
Virginia Commonwealth University
Richmond, Virginia, United States, 23298
Actively Recruiting
Research Team
R
Ryan Garten, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here