Actively Recruiting
MRI Guided Management of Occlusive Peripheral Arterial Disease
Led by The Methodist Hospital Research Institute · Updated on 2026-03-19
175
Participants Needed
1
Research Sites
256 weeks
Total Duration
On this page
Sponsors
T
The Methodist Hospital Research Institute
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to identify which plaque lesions in patients with peripheral arterial disease are impenetrable and to determine which devices minimize vessel wall injury. Patients undergoing intervention will have an MRI scan prior to their planned percutaneous vascular intervention to assess the plaque and predict procedural difficulty. Patients undergoing lower limb amputation due to peripheral arterial disease will have their limbs included into a second arm of the study The limb will undergo an MRI scan to assess the plaque. The investigator will then test two different devices and assess the effects of these devices on the vessel wall.
CONDITIONS
Official Title
MRI Guided Management of Occlusive Peripheral Arterial Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18 years or older with peripheral arterial disease (Rutherford Category 4, 5, or 6)
- At least one target lesion below the knee in native vessels in one or both limbs
- Target lesion reference vessel diameter between 2.0 and 4.0 millimeters by visual estimate
- Target lesion with greater than 50% stenosis by visual estimate
You will not qualify if you...
- Rutherford category 0, 1, 2, or 3 of the target limb
- Failure or refusal to provide written informed consent
- Contraindications to MRI
- For the second arm of the study only: chronic total occlusions
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Houston Methodist Hospital
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
T
Trisha Roy, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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