Effect of Different Exercise Types and Intensities on Muscle Recovery in Statin Users Compared to Non-Users

What this Trial Is About

Researchers are investigating how different types and intensities of exercise affect muscle recovery in people taking statin medications compared to healthy individuals not on statins. Statins are important for preventing heart problems but can cause muscle side effects, which may worsen with physical activity. The study aims to find which exercise types and intensities are best tolerated by statin users to help guide safer and more personalized exercise advice. The study compares 40 minutes of aerobic cycling at moderate intensity with resistance training at increasing intensities of 40%, 60%, and 80% of estimated one-repetition maximum strength. Resistance training involves eight machine-based exercises with sets and repetitions adjusted by intensity. Each intensity level includes two supervised sessions separated by a washout period. Participants start with endurance exercise before progressing to resistance training. The study includes statin users on stable medication and matched healthy controls. Participants undergo screening including medical history, physical exams, heart tests, and exercise testing. Baseline muscle damage markers and pain thresholds are measured. Muscle symptoms and recovery are monitored daily during the study. During exercise sessions, heart rate, blood lactate, and perceived exertion are recorded. Primary outcomes focus on changes in muscle damage markers 24 hours after exercise, with additional measures of pain, heart rate, lactate, and recovery needs. The study lasts up to 15 months overall, with each participant involved for less than 4 months.

Exercise Intensity and Muscle Recovery in Statin Users