Actively Recruiting
Exercise Intensity and Muscle Recovery in Statin Users
Led by Raffaele Mazzolari · Updated on 2026-05-04
40
Participants Needed
1
Research Sites
58 weeks
Total Duration
On this page
Sponsors
R
Raffaele Mazzolari
Lead Sponsor
U
Universitaet Innsbruck
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study aims to investigate how different types and intensities of exercise affect muscle recovery in individuals taking statin medications compared to healthy controls. Statins are essential for cardiovascular prevention but are often associated with muscle-related side effects (SAMS), which can be exacerbated by physical activity. The study will compare aerobic cycling (low muscular strain) with resistance training (RT) at increasing intensities (40%, 60%, and 80% of estimated 1-repetition maximum; e1RM). Researchers will measure markers of muscle damage, such as creatine kinase (CK) levels, and subjective recovery needs to determine which exercise modalities and intensities are best tolerated by statin users. The goal is to provide evidence for more individualized and safer exercise recommendations for this population.
CONDITIONS
Official Title
Exercise Intensity and Muscle Recovery in Statin Users
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Sedentary behavior with less than 1 hour of planned physical activity per week
- Low occupational physical activity
- Age between 30 and 65 years
- Non-smoker
- Medical clearance to participate in physical exercise from screening visit
- Current statin medication with stable dosage for at least 8 weeks prior (for statin users)
- Statin-naïve individuals (for control group)
You will not qualify if you...
- Body mass index (BMI) less than 20 kg/m² or greater than 30 kg/m²
- Smoking or quitting smoking less than 1 year ago
- Medical or musculoskeletal conditions preventing full physical effort or interfering with study measures
- Use of medications other than statins that may affect exercise or study outcomes
- Any condition found during screening (e.g., abnormal ECG or cardiopulmonary test) that makes participation unsafe according to physician
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Innsbruck
Innsbruck, Tyrol, Austria, 6020
Actively Recruiting
Research Team
R
Raffaele Mazzolari, Dr.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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