Actively Recruiting
Exercise Response in Humans With Obesity
Led by Mayo Clinic · Updated on 2025-08-29
120
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying how chronic inflammation affects muscle function and how people with obesity respond to exercise. This observational study involves adults aged 20 to 45 years who are either lean or obese. The goal is to better understand muscle protein synthesis and gene responses related to exercise in these groups. Participants are divided into two groups based on body mass index (BMI): a lean group with BMI between 20 and 25 kg/m² and an obese group with BMI between 30 and 45 kg/m². Each participant completes an outpatient visit including body composition measurement, blood tests, a treadmill fitness test, and a strength test. They also have an inpatient visit involving muscle and fat biopsies, indirect calorimetry to measure resting energy use, and an exercise test. During the study, researchers collect data at baseline and about 8 hours after exercise to measure changes in muscle protein synthesis, gene expression, and activation of signaling proteins. Participants will undergo imaging with magnetic resonance imaging (MRI) of the upper leg to examine fat and muscle. The study carefully monitors physical fitness, muscle strength, and metabolic responses to exercise over the study period, which extends through July 2029.
CONDITIONS
Brief Title
Exercise Response in Humans With Obesity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Obese men and women aged 20 to 45 years
You will not qualify if you...
- Diabetes or fasting plasma glucose above 126 mg/dL
- Anemia (hemoglobin less than 11 g/dL for females and less than 12 g/dL for males)
- Active coronary artery disease or history of unstable macrovascular disease within 3 months
- Renal failure with serum creatinine above 1.5 mg/dL
- Chronic active liver disease with elevated liver enzymes (AST >144 IU/L or ALT >165 IU/L)
- Use of oral warfarin or history of blood clotting disorders
- Smoking
- Pregnancy or breastfeeding
- Alcohol consumption greater than 2 glasses per day or substance abuse
- Untreated or uncontrolled hypothyroidism
- Debilitating chronic disease as determined by investigators
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants complete outpatient study visits involving body composition measurement, blood draw, treadmill test, and strength test to assess fitness and muscle strength.
1 outpatient visit (in-person)
Duration - 1 day
Participants complete an inpatient visit that includes muscle biopsies, fat biopsies, indirect calorimetry to measure resting energy expenditure, and exercise testing to evaluate exercise response.
1 inpatient visit (in-person)
Trial Site Locations
Total: 1 location
1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
R
Rachel Passehl
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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