Actively Recruiting
Exploration and Evaluation of Amygdalo-Hippocampectomy According to Prof. Coubes' Technique: An Anatomical, Clinical, and Educational Approach
Led by University Hospital, Montpellier · Updated on 2025-04-08
3504
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to evaluate the long-term outcomes and complications of amygdalo-hippocampectomy using the surgical method developed by Professor Coubes at the University Hospital of Montpellier. It focuses on patients treated for hippocampal sclerosis and other internal temporal diseases, investigating factors associated with better seizure control and the evolution of clinical results. The study includes data from 234 patients treated over the past 30 years, covering both adults and children. The study analyzes clinical information retrospectively, including demographics, surgical and imaging data, and seizure outcomes based on ILAE criteria. It examines post-operative complications, return-to-work rates, and social reintegration. The method studied features precise anatomical targeting and surgical pathways designed to reduce neurological deficits and improve seizure control, distinguishing it from other surgical techniques such as the Yasargil approach. Participants' medical records will be reviewed to collect data on seizure control, complications like infections and hematomas, and medication use before and after surgery. Statistical analyses will identify predictors of success or failure after surgery. The study spans from 2024 to 2025 and ensures data privacy by pseudonymizing patient information. Results aim to provide clinical insights, comparative perspectives, and educational value in neurosurgical practice.
CONDITIONS
Brief Title
Exploration and Evaluation of Amygdalo-Hippocampectomy According to Prof. Coubes' Technique: An Anatomical, Clinical, and Educational Approach
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients who had undergone an Amygdalo-Hippocampectomy according to the surgical procedure described by Professor Coubes
You will not qualify if you...
- Patients who did not have this exact procedure
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Surgery plus immediate recovery period
Participants undergo the Amygdalo-Hippocampectomy surgery using Pr. Coubes' technique followed by immediate post-operative care to manage surgical recovery and complications.
1 surgery visit and several immediate post-operative assessments
Duration - Up to 20 years following surgery
Participants are monitored long-term for seizure control, post-operative complications, medication adjustments, and overall functional reintegration after surgery.
Periodic follow-up visits over years up to 20 years
Trial Site Locations
Total: 1 location
1
CHU de Montpellier
Montpellier, Hérault, France, 34000
Actively Recruiting
Research Team
P
Pierre-Olivier MOSER, Medical Doctor
G
Gaetan POULEN, MD, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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