Actively Recruiting
Exploration of GCase Activity to Identify a Subpopulation Eligible for a Therapeutic Trial in Dementia With Lewy Bodies
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2025-11-20
236
Participants Needed
1
Research Sites
171 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research focuses on the activity of an enzymatic protein: glucocerebrosidase, in dementia with lewy bodies (DLB). Indeed, the mutation of the GBA gene responsible for a decrease in the activity of glucocerebrosidase is the most frequent known genetic risk factor in DLB. However, mutations of the GBA gene are known in another pathology, Gaucher disease, in which treatments have been developed. The objective of this research is to determine if glucocerebrosidase activity is decreased in DLB. This hypothesis could open up a therapeutic perspective, with treatments already used in Gaucher disease.
CONDITIONS
Official Title
Exploration of GCase Activity to Identify a Subpopulation Eligible for a Therapeutic Trial in Dementia With Lewy Bodies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged 60; 50 years old
- Presence of an accompanying person
- Dementia with Lewy bodies according to the revised criteria of Mc Keith 2017
- Male or female aged 60; 50 years old
- Absence of cognitive impairment and clinical element for a neurodegenerative disease
You will not qualify if you...
- Other neurodegenerative disease
- Gaucher disease
- Neurodegenerative disease
- Cognitive impairment of all causes
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Centre de neurologie Cognitive
Paris, France, France, 75010
Actively Recruiting
Research Team
C
Claire HOURREGUE, MD
CONTACT
C
Claire PAQUET, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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