Actively Recruiting
Exploratory Observational Prospective Study in Neonatal and Pediatric Congenital Diaphragmatic Hernia
Led by McGill University Health Centre/Research Institute of the McGill University Health Centre · Updated on 2024-11-22
80
Participants Needed
1
Research Sites
299 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
CDH is associated with lung hypoplasia, pulmonary hypertension, and left ventricular hypoplasia. Use of new STE techniques (heart ultrasound) showed that CDH newborns have decreased LV size and function, potentially explaining the non-response to iNO, and that these cardiac findings were associated with poor outcomes. Our hypothesis: CDH newborns persist to have some degree of LV hypoplasia in the pediatric and adolescent life and pulmonary pressures remain increased during growth. Patients with decreased cardiac performance by STE and/or with PH have higher concomitant neonatal or pediatric morbidities and altered neurodevelopmental profile
CONDITIONS
Official Title
Exploratory Observational Prospective Study in Neonatal and Pediatric Congenital Diaphragmatic Hernia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with congenital diaphragmatic hernia (CDH) and admitted to the MCH NICU
- Diagnosed with CDH and followed at the MCH CDH clinic
You will not qualify if you...
- Born before 36 weeks of gestation
- CDH diagnosis made after 7 days of life
- Bilateral congenital diaphragmatic hernia
- Presence of major congenital heart defects (except PDA, ASD, or VSD) or other major anomalies/genetic syndromes
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Mcgill University Health Centre
Montreal, Quebec, Canada, H4A 3J1
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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