Actively Recruiting
Exploring Parameters of Driving Simulation in Relation to Drug Holidays in ADHD Patients
Led by Stefan Lakämper · Updated on 2025-06-05
26
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
S
Stefan Lakämper
Lead Sponsor
P
Psychiatric University Hospital, Zurich
Collaborating Sponsor
AI-Summary
What this Trial Is About
Attention Deficit Hyperactivity Disorder (ADHD) is associated with an increased risk of traffic accidents due to inattentiveness. This trial focuses on adult drivers with ADHD who are treated with stimulant medications and often take planned breaks from their medication, called "drug holidays." The study aims to explore how these medication breaks affect driving performance, addressing a significant gap in current research. Participants in this interventional trial will be randomly assigned to one of two groups. Both groups will undergo driving simulation tests while medicated and during a drug holiday, which involves skipping three consecutive doses of stimulant medication. The groups differ in the sequence of testing: one group tests medicated twice before the drug holiday, while the other alternates between medicated and drug holiday states. This design allows comparison of driving performance under both conditions. During the study, participants will complete driving simulation assessments at various time points, including during medication and drug holiday phases. Eye tracking will be used, requiring participants to wear contact lenses if needed. The main outcome measured is the difference in integrated driving scores (IDS) between medicated and drug holiday states over several days. Safety and participant ability to follow the study procedures will be monitored throughout the trial.
CONDITIONS
Brief Title
Exploring Parameters of Driving Simulation in Relation to Drug Holidays in ADHD Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult drivers
- Diagnosed with ADHD and treated only with stimulant medications
- History of taking drug holidays based on own decision
- Impaired eyesight greater than +/- 5 diopters or astigmatism
- Use of contact lenses required for eye tracking
You will not qualify if you...
- Sensitivity to motion sickness, dizziness, or similar symptoms within 5 minutes of driving
- Treatment with non-stimulant medications
- Inability to understand the study procedures due to language or cognitive reasons
- Professional drivers actively working during the study period
- Pregnant women
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Variable based on test sequences with at least 4 days between conditions
Participants undergo sequences of medicated states and "drug holidays" by omitting three consecutive daily doses of ADHD medication to assess driving simulation performance.
3 visits corresponding to each testing condition
Trial Site Locations
Total: 1 location
1
Division of Traffic Medicine, Institute of Forensic Medicine, University of Zurich,
Zurich, ZRH, Switzerland, 8050
Actively Recruiting
Research Team
S
Stefan Lakämper, Dr. rer. nat.
N
Nan Li, MSc
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
PREVENTION
Number of Arms
2
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