Studying Driving Simulation Performance During Medication Breaks in Adults with ADHD Taking Stimulant Treatment

What this Trial Is About

Attention Deficit Hyperactivity Disorder ADHD is associated with an increased risk of traffic accidents due to inattentiveness. This trial focuses on adult drivers with ADHD who are treated with stimulant medications and often take planned breaks from their medication, called drug holidays. The study aims to explore how these medication breaks affect driving performance, addressing a significant gap in current research. Participants in this interventional trial will be randomly assigned to one of two groups. Both groups will undergo driving simulation tests while medicated and during a drug holiday, which involves skipping three consecutive doses of stimulant medication. The groups differ in the sequence of testing one group tests medicated twice before the drug holiday, while the other alternates between medicated and drug holiday states. This design allows comparison of driving performance under both conditions. During the study, participants will complete driving simulation assessments at various time points, including during medication and drug holiday phases. Eye tracking will be used, requiring participants to wear contact lenses if needed. The main outcome measured is the difference in integrated driving scores IDS between medicated and drug holiday states over several days. Safety and participant ability to follow the study procedures will be monitored throughout the trial.

Exploring Parameters of Driving Simulation in Relation to Drug Holidays in ADHD Patients