Actively Recruiting
Predictive Value of Electroencephalography Features in Perioperative Neurocognitive Disorders in Patients Undergoing Cardiovascular Surgery Under General Anaesthesia: A Prospective Observational Study
Led by Beijing Chao Yang Hospital · Updated on 2025-05-30
100
Participants Needed
1
Research Sites
25 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the ability of electroencephalography (EEG) features to predict perioperative neurocognitive disorders (PND) in patients undergoing cardiovascular surgery under general anesthesia. This observational study focuses on identifying EEG brain network-related indexes before and after surgery to understand their relationship with cognitive changes following heart bypass or valve replacement surgeries. The study is sponsored by Beijing Chao Yang Hospital and aims to improve understanding of cognitive risks after cardiovascular procedures. Patients undergo cardiovascular surgeries such as coronary artery bypass or valve replacement under general anesthesia. EEG data is collected using a 32-channel EEG cap with a 10-20 system both before and after surgery. Cognitive function is assessed using the Montreal Cognitive Assessment (MoCA) one day before and one week after surgery, with a follow-up phone assessment one month later using the Telephone version of MoCA (T-MoCA). Postoperative delirium is evaluated using the confusion assessment method (CAM) or CAM for the intensive care unit (CAM-ICU). Participants are involved in cognitive testing before surgery, during the first week after surgery, and one month following surgery. Researchers assess EEG features and monitor cognitive function changes to identify predictive markers for postoperative cognitive dysfunction and delirium. The primary outcome is the predictive value of preoperative EEG features for postoperative cognitive dysfunction. Secondary outcomes include EEG features related to postoperative delirium. The study will conclude assessments by August 2025, with participant involvement lasting approximately one month after surgery.
CONDITIONS
Brief Title
Exploring the Predictive Value of Electroencephalography Features in Perioperative Neurocognitive Disorders Following Cardiovascular Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Written informed consent
- Undergoing coronary artery bypass surgery or valve replacement surgery under general anaesthesia
- ASA grade II to IV
- Older than 60 years
- Able to complete cognitive function tests
You will not qualify if you...
- History of severe neurological diseases or psychiatric diseases
- History of drug abuse
- Severe hearing or vision impairment
- Preoperative delirium
- Serious adverse reactions like cardiac arrest or cardiopulmonary resuscitation during surgery
- Patients undergoing secondary surgery in a short period
- Participation in concurrent clinical trials
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) for eligibility assessment and informed consent
Duration - 1 day before surgery
Participants undergo cognitive assessments and electroencephalography (EEG) recordings before surgery to evaluate baseline cognitive function and brain activity.
1 visit (in-person) for cognitive testing and EEG
Duration - Day of surgery and immediate recovery period
Participants undergo cardiovascular surgery under general anesthesia, including heart bypass or valve replacement surgery, with post-operative delirium assessment.
1 visit (in-person) for surgery and immediate post-operative monitoring
Duration - 7 ± 2 days after surgery
Participants complete cognitive assessments one week after surgery to evaluate perioperative neurocognitive disorders.
1 visit (in-person) for cognitive testing
Duration - 30 ± 2 days after surgery
Participants are followed up one month after surgery with telephone cognitive assessments to monitor longer-term cognitive outcomes.
1 visit (telephone) for cognitive assessment
Trial Site Locations
Total: 1 location
1
Beijing Chao Yang Hospital
Beijing, Beijing Municipality, China, 100020
Actively Recruiting
Research Team
C
Changwei Wei, doctor
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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