Actively Recruiting
Nutritional Intervention in the Modulation of Postoperative Metabolism in Cardiovascular Surgery
Led by Fu Jen Catholic University · Updated on 2026-03-27
30
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to study the distribution of gut microbiota-derived metabolites in patients undergoing cardiovascular surgery and to evaluate whether postoperative nutritional intervention with probiotics can influence the gut-heart metabolic axis. The goal is to see if this modulation can improve metabolic profiles and clinical outcomes related to cardiovascular disease, which remains a leading cause of death worldwide. The study also seeks to understand how these metabolites, linked to inflammation and vascular issues, are present in heart tissues and blood. Participants will have preoperative blood samples taken and cardiac tissue collected during surgery for detailed metabolite analysis using mass spectrometry. After surgery, some participants will receive probiotic supplements alongside standard postoperative care, while others will receive a placebo with standard care. Blood samples will be collected over time to monitor changes in metabolome and gut microbial composition during the 3-week intervention period. During the study, participants will provide blood and tissue samples and may receive probiotic or placebo supplements after surgery. Researchers will measure levels of specific gut microbiota-derived metabolites such as trimethylamine-N-oxide, phenylacetylglutamine, p-cresyl sulfate, and indoxyl sulfate from enrollment through the 3-week intervention. The trial includes randomization and double-blinding to ensure unbiased results, with continuous monitoring of metabolic changes and clinical outcomes through this period.
CONDITIONS
Brief Title
Nutritional Effects in Cardiovascular Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Scheduled to undergo cardiovascular surgery
- Completed preoperative clinical and imaging evaluations
- Willing to provide informed consent
- Willing to receive potential probiotic supplementation
You will not qualify if you...
- Use of antibiotics, probiotics, or other treatments affecting gut microbiota within 4 weeks
- History of major gastrointestinal disease
AI-Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) for preoperative clinical and imaging evaluations
Duration - Day of surgery
Participants undergo cardiovascular surgery with collection of blood and cardiac tissue samples during the procedure.
1 surgical visit (in-person)
Duration - 3 weeks
Participants receive standard postoperative care with either probiotic or placebo supplementation to modulate postoperative metabolism.
Weekly visits for postoperative monitoring and blood sample collection
Trial Site Locations
Total: 1 location
1
Fu Jen Catholic University Hospital, Fu Jen Catholic University
New Taipei City, Taiwan, 24352
Actively Recruiting
Research Team
K
Ke-Yun Chao, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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