Actively Recruiting
Familial Hypercholesterolemia Interpretive Comment - Nudging to Detection.
Led by Odense University Hospital · Updated on 2026-02-20
2000
Participants Needed
2
Research Sites
178 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Familial hypercholesterolemia is the most common inherited disease of the lipid metabolism, however it remains underdiagnosed. Only 15 % of 30.000 possible patients have been found in Denmark. This quality assessing project will through a step wedge cluster randomized controlled trial evaluate establishment of a biochemistry interpretive comment on elevated LDL-C levels. The study will test if the comment results in an increase in referred patients to the lipid clinics of Southern Denmark as the primary endpoint, and as the secondary endpoint in more patients diagnosed with familial hypercholesterolemia. The project will run in totally 52 weeks and will in steps initiate the comment from the different laboratories in the Region of Southern Denmark.
CONDITIONS
Official Title
Familial Hypercholesterolemia Interpretive Comment - Nudging to Detection.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- All patients referred to the lipid clinics of Southern Denmark
- LDL-C 24 4 mmol/L in persons under 40 years old
- LDL-C 25 5 mmol/L in persons 40 years or older
You will not qualify if you...
- Pregnancy
- Secondary dyslipidemia including:
- Dysregulated diabetes with HbA1c C 48
- Dysregulated hypothyroidism with elevated TSH
- Combined hyperlipidemia with triglycerides > 4 mmol/L
- Nephrotic syndrome with proteinuria > 3 g/L and serum albumin < 30 g/L
- Cholestasis with alkaline phosphatase > 105 U/L and GGT > 55 U/L within 14 days prior to LDL-C measurement
- Drug-induced hyperlipidemia
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Odense University Hospital
Odense, Funen, Denmark, 5000
Actively Recruiting
2
Departement of Cardiology, Odense University Hospital
Odense C, Denmark, 5000
Actively Recruiting
Research Team
J
Jakob Knold, MD
CONTACT
F
Finn Lund Henriksen, Ph.d.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
SCREENING
Number of Arms
2
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