Actively Recruiting
Fatigue and Cognitive Dysfunction Due to Synaptopathy or Graft Versus Host Disease in the Brain
Led by Karolinska University Hospital · Updated on 2026-01-26
30
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
Sponsors
K
Karolinska University Hospital
Lead Sponsor
K
Karolinska Institutet
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying fatigue and cognitive dysfunction in patients who have undergone allogenic stem cell transplantation. The study focuses on understanding how inflammation affects brain synaptic density and glial cell activation, which may contribute to mental fatigue and cognitive problems. This observational research is conducted at Karolinska University Hospital and includes patients both with and without these symptoms. Participants will have access to advanced PET imaging, with two PET scans performed as part of the research. Liquor samples are also collected for detailed immunological and radio-morphological studies. These procedures help explore the underlying causes of fatigue and cognitive dysfunction after transplantation. During the study, patients are regularly followed up at the outpatient clinic. Researchers will systematically measure fatigue and cognitive impairment using international standards. The main outcome is to investigate the role of inflammation in brain changes linked to these symptoms. The study runs from 2024 to 2027, with ongoing monitoring and data collection.
CONDITIONS
Brief Title
Fatigue and Cognitive Dysfunction Due to Synaptopathy or Graft Versus Host (GVH) Disease in the Brain.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- PET images available retrospectively
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Time of imaging assessments
Participants undergo two advanced PET investigations to assess inflammation and synaptic density related to fatigue and cognitive dysfunction.
2 visits (in-person)
Trial Site Locations
Total: 1 location
1
Ksenia Boriskina
Stockholm, Sweden, 14186
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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