Actively Recruiting
Study on Fatigue and Cognitive Problems Caused by Brain Synaptopathy or Graft Versus Host Disease in Adults Undergoing Stem Cell Transplantation
Led by Karolinska University Hospital · Updated on 2026-01-26
30
Participants Needed
1
Research Sites
52 weeks
Total Duration
AI-Summary
What this Trial Is About
Researchers are studying fatigue and cognitive dysfunction in patients who have undergone allogenic stem cell transplantation. The study focuses on understanding how inflammation affects brain synaptic density and glial cell activation, which may contribute to mental fatigue and cognitive problems. This observational research is conducted at Karolinska University Hospital and includes patients both with and without these symptoms. Participants will have access to advanced PET imaging, with two PET scans performed as part of the research. Liquor samples are also collected for detailed immunological and radio-morphological studies. These procedures help explore the underlying causes of fatigue and cognitive dysfunction after transplantation. During the study, patients are regularly followed up at the outpatient clinic. Researchers will systematically measure fatigue and cognitive impairment using international standards. The main outcome is to investigate the role of inflammation in brain changes linked to these symptoms. The study runs from 2024 to 2027, with ongoing monitoring and data collection.
CONDITIONS
Brief Title
Fatigue and Cognitive Dysfunction Due to Synaptopathy or Graft Versus Host (GVH) Disease in the Brain.
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