Investigation of How Fructose Consumption Affects Intestinal Barrier and Health in Healthy Adults

What this Trial Is About

Researchers are studying how consuming fructose affects health and the intestinal barrier in healthy adults. This randomized, single-blind crossover trial compares the effects of drinks supplemented with low doses of free fructose versus free glucose after participants standardize their nutritional intake for three days. The study aims to better understand changes in intestinal permeability and immune cell responses to bacterial toxins. Participants will first follow a nutritional standardization period of three days. Then, they will receive a drink with 5% free fructose or 5% free glucose. Each participant receives both interventions in different periods, allowing comparison of their effects on health parameters related to the intestines and immune system. During the study, researchers will measure markers of intestinal permeability and cytokine release from blood immune cells stimulated with bacterial toxins at the end of each one-month treatment period. Participants will be monitored for changes in these health indicators. The trial includes healthy adults aged 18 and older, with no upper age limit specified, and continues until December 2027.

Fructose and (Aging)