Observational Study of BK Virus Types and Immune Response in Kidney Transplant Patients with Urinary BK Virus

What this Trial Is About

Researchers are studying the BK polyomavirus BKV in kidney transplant recipients, focusing on understanding the source of the virus when it replicates in the urinary tract. The study aims to determine if the BKV detected in patients comes from the donor kidney or from the recipients own viral reactivation. It also explores how the immune response relates to the viruss genotype and whether new biomarkers can help predict viral replication and spread in the body. This observational study groups patients based on their BKV replication profile those with virus only in urine viruria and those with virus in both urine and blood viremia. Kidney transplant recipients with BKV viruria during routine follow-up at the university hospital are included. No extra visits are required beyond standard clinical care, and additional blood samples will be collected during these scheduled visits to analyze viral and immune markers. Participants will be monitored up to two years, with researchers measuring the prevalence and types of BKV genotypes and serotypes, comparing viral loads, immune responses, and the presence of viral microRNAs and chemokines. The study evaluates associations between viral characteristics and immune function, as well as the impact of immunosuppressive treatments. Safety and kidney function are followed through routine clinical assessments during this period.

Study of the Serotype and Genotype of BK Virus in Kidney Transplant Recipients and Their Donors to Identify Individuals at Risk of Nephropathy