Study of Genetic Factors in Familial and Sporadic Pituitary Tumors Including Acromegaly and Gigantism

What this Trial Is About

Researchers are studying genes that may increase the risk of endocrine tumors, focusing primarily on pituitary adenomas such as growth hormone-secreting tumors somatotrophinomas and prolactinomas. The study aims to identify and understand the role of genes like AIP and related molecules in familial and sporadic pituitary tumors. The goal is to learn how these genes contribute to tumor development and to extend findings to other pituitary-related conditions. Participants will be recruited from endocrine clinics and other medical departments, especially those with inherited conditions indicated by early onset, multiple tumors, or affected family members. Blood samples and tumor tissue will be collected for genetic and protein studies. The research includes analysis of gene mutations, RNA expression, and protein levels using methods such as gene sequencing, RT-PCR, Western blotting, and immunohistochemistry. Participants will provide blood and, when applicable, tumor samples, which will be coded for privacy. Researchers will analyze these samples over a 10-year period for germline mutations and genetic markers. Family members may also be invited to participate to help identify inherited gene patterns. The study involves ongoing genetic assessments and monitoring to better understand endocrine tumor predisposition and gene function.

Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA