The Genetic Contribution to Progression of Kidney Disease

What this Trial Is About

Researchers are studying the role of genetics in the development and progression of various kidney diseases, including acute kidney injury (AKI), chronic kidney disease (CKD), hypertension, autosomal dominant polycystic kidney disease (ADPKD), CKD-mineral and bone disorder (CKD-MBD), patients with decompensated heart failure, hematologic cancer patients undergoing chemotherapy or bone marrow transplantation, and glomerular diseases. The study aims to better understand how genetic and environmental factors interact to influence disease progression and complications, including cardiovascular issues in CKD patients. The study involves observational assessment of patients grouped by specific kidney-related conditions such as chronic and acute nephropathies, nephrectomy, major surgery candidates, decompensated heart failure, acute critical illness, hypertension, hematologic cancer, and long-term bone marrow transplantation survivors. Researchers will analyze genetic polymorphisms related to kidney function, blood pressure regulation, and other pathways. Patients may be assessed individually or with their families to study phenotypic differences and genetic modifiers. The study also evaluates the impact of drugs and nutritional factors like salt and protein intake on disease progression. Participants will undergo genetic testing and clinical evaluations over time, with monitoring of kidney function including glomerular filtration rate changes from days up to 35 years according to genetic profiles. Data collection includes assessing cardiovascular complications, bone lesions in CKD, and biochemical factors related to genetics and nutrition. This long-term observational study involves regular assessments to track disease progression and genetic influences, contributing to improved classification and management of kidney diseases.

Genetics in the Progression of Nephropathies