Actively Recruiting
GLOW: Gender-Affirming Care and Mental Health A Longitudinal Study On Quality of Life, Work Life, and Healthcare Outcomes
Led by Region Skane · Updated on 2026-05-18
500
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying gender-affirming care and its impact on mental health, quality of life, work capacity, and healthcare outcomes for adults diagnosed with gender dysphoria in Sweden. This longitudinal study explores psychological, medical, and social factors affecting treatment results and aims to understand how gender-affirming care influences psychiatric symptoms, self-concept clarity, mortality, and healthcare use compared to similar individuals without gender dysphoria. The study is based at a National Highly Specialized Care unit, ensuring consistent data collection and clinical follow-up. The investigation uses a mixed-methods design combining national registry data, self-reported assessments, and qualitative interviews. Participants receive gender-affirming care according to standardized clinical procedures within the specialized clinic. Data are collected at baseline, after approximately one year, and then at 24 and 60 months to monitor changes in quality of life, mental health symptoms, gender congruence, work capacity, and healthcare utilization. The study also compares outcomes with an age- and gender-matched control group. Participants will complete questionnaires and assessments periodically over five years, including measures of quality of life, anxiety, substance use, identity functioning, and work participation. Researchers will analyze registry data for mortality and healthcare resource use. The study involves long-term follow-up through standardized clinical visits and registry reviews to provide a comprehensive understanding of gender-affirming care effects over time. Total participation can last up to five years with repeated evaluations and interviews.
CONDITIONS
Brief Title
GLOW: Gender-Affirming Care and Mental Health: A Longitudinal Study On Quality of Life, Work Life, and Healthcare Outcomes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Referred to the NHV clinic for gender dysphoria assessment in Region Skåne
You will not qualify if you...
- Unable to read or write Swedish
- Have a protected identity status
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Approximately 1 year
Participants undergo clinical assessment for gender dysphoria and baseline measurements are collected.
Assessments at the beginning and end of the clinical evaluation period (usually 1 year apart)
Duration - Up to 60 months
Participants are followed over time to assess quality of life, mental health, work capacity, and healthcare utilization.
Follow-up assessments at 24 months and 60 months
Trial Site Locations
Total: 1 location
1
The Gender Dysphoria Clinic at Skåne University Hospital, Malmö, Sweden
Malmö, Malmö, Sweden
Actively Recruiting
Research Team
E
Emma Claesdotter-Knutsson, MD; Ass prof
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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