Actively Recruiting
Evaluation of Chronic Pathologies Impact and Their Treatments on Children and Teen Physical Fitness
Led by University Hospital, Clermont-Ferrand · Updated on 2019-05-08
300
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University Hospital, Clermont-Ferrand
Lead Sponsor
L
Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying children and adolescents aged 6 to 18 years who have chronic pediatric diseases such as juvenile idiopathic arthritis, type 1 diabetes, inflammatory bowel diseases, anorexia nervosa, or are cancer survivors. The research aims to understand how these chronic diseases and their treatments affect physical fitness, including muscle function, metabolism, and body composition. This project seeks to improve treatments by combining assessments of muscle structure, function, and metabolism, considering disease activity and maturation status. Participants will be grouped by disease status (active or inactive) and by treatment type to evaluate the impact on physical fitness. They will undergo various physical tests including graded exercise tests with indirect calorimetry to measure metabolism, ultrasound for muscle architecture, peripheral quantitative tomography for muscle quality and bone micro-architecture, isokinetic dynamometer tests for muscle strength and fatigue, vertical jump tests, and body composition analysis by dual-energy X-ray absorptiometry. Blood samples will be collected annually to assess inflammation and metabolic markers. During the study, participants will perform physical and metabolic assessments to measure muscle function, fatigue, body composition, and inflammatory status. Researchers will monitor maximal lipid oxidation during exercise as the primary outcome, along with secondary outcomes such as muscle strength, architecture, fatigue, body composition, and various blood biomarkers. The study includes healthy children matched by age and gender as controls. Participants' physical activity and medical status will be evaluated to develop future guidelines for physical activity during treatment. The study duration and follow-up details vary with annual blood sampling and periodic physical assessments.
CONDITIONS
Brief Title
Health and Exercise Response in Children With Chronic and Auto-immune Pathologies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ages between 6 and 18 years
- Male or female
- Diagnosed with a chronic disease or receiving treatment known to affect muscle mass, metabolism, or body composition
- Registered at the hospital center of Clermont-Ferrand (patients)
- Free and informed consent provided by the patient and parental authority holders
- Affiliated with the social security system (controls)
You will not qualify if you...
- Treatment with systemic corticosteroids for more than one week in the 30 days before testing (patients)
- Any contraindication to practicing sports
- Active infection
- Having a chronic disease or treatment that can alter muscle mass, metabolism, or body composition (controls)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants complete physical tests including metabolic flexibility, muscle architecture and quality, muscle function and fatigue, bone micro-architecture, and body composition assessments. Blood samples are also collected to evaluate inflammatory markers and other biological parameters.
1 visit (in-person)
Duration - 6 months
Participants undergo follow-up assessments to measure muscle architecture, body composition, and muscle fatigue to monitor changes over time.
1 visit (in-person)
Duration - Once per year
Participants have blood samples drawn annually to assess inflammatory state and other biological markers relevant to their condition.
1 visit (in-person) annually
Trial Site Locations
Total: 1 location
1
Chu Clermont-Ferrand
Clermont-Ferrand, France, 63003
Actively Recruiting
Research Team
L
Lise LACLAUTRE
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
2
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