Actively Recruiting
A Biological Atlas of Severe Obesity (Biological Tissue Collection)
Led by University Hospital, Lille · Updated on 2025-12-08
20000
Participants Needed
1
Research Sites
1094 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Type 2 diabetes and obesity are both multifactorial diseases resulting from gene-environment interactions. However, this interaction, as well as the specific effect of each polymorphism, remains poorly understood. We now proposed a prospective cohort study to improve our understanding of the influence of phenotypic characteristics on gene expression in tissues involved in glucose and/or lipid metabolism by collecting different biological samples.
CONDITIONS
Official Title
A Biological Atlas of Severe Obesity (Biological Tissue Collection)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 65 years
- Scheduled for abdominal surgery requiring laparotomy or laparoscopy such as bariatric surgery, gallbladder removal, or abdominal wall surgery
- Have one of the following phenotypes:
- BMI ≥ 35 kg/m2 with diabetes defined by fasting blood glucose ≥ 7 mmol/L and/or blood glucose ≥ 11.1 mmol/L 120 minutes after glucose ingestion
- BMI ≥ 35 kg/m2 with glucose intolerance defined by fasting blood glucose > 6 mmol/L and < 7 mmol/L and/or blood glucose > 7.8 mmol/L and < 11.1 mmol/L 120 minutes after glucose ingestion
- BMI ≥ 35 kg/m2 without diabetes defined by blood glucose ≤ 6 mmol/L and/or ≤ 7.8 mmol/L 120 minutes after glucose ingestion
- BMI < 27 kg/m2 without diabetes defined by blood glucose ≤ 6 mmol/L and/or ≤ 7.8 mmol/L 120 minutes after glucose ingestion
- BMI between 27 and 35 kg/m2 without diabetes defined by blood glucose ≤ 6 mmol/L and/or ≤ 7.8 mmol/L 120 minutes after glucose ingestion
You will not qualify if you...
- Unable to receive clear information
- Refusal to sign the consent form
- Presence of a pathology judged by the surgeon that may increase the risk of adverse events related to tissue sampling
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Lille University Hospital
Lille, Nord, France
Actively Recruiting
Research Team
F
Francois PATTOU, MD PhD
CONTACT
V
Violeta Raverdy, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
5
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