What is this study trying to find out about obesity and diabetes?

This study aims to understand how genetic differences affect gene activity in tissues related to glucose and fat metabolism in people with obesity and type 2 diabetes. By studying gene expression and clinical features, researchers hope to learn more about the combined condition called "diabesity." The study is led by the University Hospital, Lille.

Who may be eligible for this obesity and diabetes clinical trial?

Adults aged 18 to 65 who are scheduled for abdominal surgery such as bariatric surgery or gallbladder removal may be eligible. Participants should fall into groups based on their body mass index and diabetes or glucose intolerance status. Both males and females can participate. Please review eligibility criteria for more details.

Is there any cost to participate in this obesity and diabetes clinical trial?

Study-related care, including all study procedures and visits, is provided at no cost. However, personal travel and related expenses may vary and are not guaranteed to be covered by the study.

Actively Recruiting

Age: 18Years - 65Years

All Genders

Healthy Volunteers

ID01129297

Influence of the Glycemic and Ponderal Status on Tissues Gene Expression Biological Tissue Collection for Obesity and Diabetes

Led by University Hospital, Lille · Updated on 2025-12-08

20000

Participants Needed

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

Researchers are investigating the relationship between obesity and type 2 diabetes, conditions influenced by both genetic and environmental factors. This study aims to better understand how different genetic variations affect gene expression in tissues involved in glucose and lipid metabolism, which may contribute to what is called diabesity, a combined condition of diabetes and obesity. The study uses advanced genomic techniques and bioinformatics to analyze these factors in both humans and animal models. Participants in this observational study are grouped based on their body mass index BMI and diabetes or glucose intolerance status. Groups include individuals with BMI 35 kgm2 with diabetes, glucose intolerance, or without diabetes, as well as those with BMI 27 kgm2 and BMI between 27 and 35 kgm2 without diabetes. Samples are collected during abdominal surgeries such as bariatric surgery or cholecystectomy to study gene expression and metabolic pathways. During the study, researchers collect biological samples at baseline and follow participants over several years to assess changes in gene expression and insulin resistance. They also evaluate clinical and biological features before and after bariatric surgery at 1, 2, and 5 years. The primary measurement focuses on gene expression in tissues related to glucose metabolism. This long-term observation helps to understand the genetic and phenotypic factors influencing obesity and diabetes, with participation lasting up to 5 years.

CONDITIONS

Brief Title

A Biological Atlas of Severe Obesity (Biological Tissue Collection)

Who Can Participate

Age: 18Years - 65Years

All Genders

Healthy Volunteers

Eligibility Criteria

You may qualify if you...

Age between 18 and 65 years
Scheduled for abdominal surgery requiring laparotomy or laparoscopy such as bariatric surgery, gallbladder removal, or abdominal wall surgery
Body Mass Index (BMI) ≥ 35 kg/m2 with diabetes (fasting blood glucose ≥ 7 mmol/l and/or ≥ 11.1 mmol/l after 120 minutes of glucose ingestion)
Body Mass Index (BMI) ≥ 35 kg/m2 with glucose intolerance (fasting blood glucose > 6 mmol/L and < 7 mmol/l and/or > 7.8 mmol/l and < 11.1 mmol/l after 120 minutes of glucose ingestion)
Body Mass Index (BMI) ≥ 35 kg/m2 without diabetes (blood glucose ≤ 6 mmol/L and/or ≤ 7.8 mmol/l after 120 minutes of glucose ingestion)
Body Mass Index (BMI) < 27 kg/m2 without diabetes (blood glucose ≤ 6 mmol/L and/or ≤ 7.8 mmol/l after 120 minutes of glucose ingestion)
Body Mass Index (BMI) between 27 and 35 kg/m2 without diabetes (blood glucose ≤ 6 mmol/L and/or ≤ 7.8 mmol/l after 120 minutes of glucose ingestion)

You will not qualify if you...

Unable to receive clear information about the study
Refusal to sign the consent form
Any pathology judged by the surgeon to increase risk of adverse events related to tissue sampling

Research Team

Francois PATTOU, MD PhD

Violeta Raverdy, MD

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