Study on High Resolution Anuscopy for Detecting Precancerous Anal Lesions in Adults

What this Trial Is About

Anal squamous cell carcinoma SCC is mostly caused by infection with high-risk human papillomavirus HPV. Although anal SCC is rare in the general population, certain high-risk groups are affected more often. These groups are screened using anal swabs to check for abnormal cells and high-risk HPV. Referral for high resolution anoscopy HRA is advised when abnormal results are found. HRA is the only method to detect precancerous lesions in the anal canal but requires specialized expertise. This observational study at Universitair Ziekenhuis Brussel involves collecting and analyzing data on HPV infection and its link to anal disease. Participants include patients who have had or will be referred for HRA at this center. The study aims to explore the prevalence of precancerous lesions among different risk groups, such as men who have sex with men using PrEP or living with HIV. It also examines associations between abnormal tissue findings, patient characteristics, and HPV infection patterns over an average of 5 years. Participants will undergo HRA as part of their care, and data from these procedures will be studied. Researchers will measure the prevalence of precancerous lesions, abnormal histology, and anal cancer in these at-risk populations. The study will also correlate abnormal tissue and cell findings with HPV infection status. Participation involves data collection through routine clinical care without additional interventions. The study continues until 2029, providing long-term insights into anal cancer risks and HPV-related changes.

High Resolution Anuscopy Study