Anal Monitoring for Women Aged 18 and Older With a History of High-Grade HPV-Related Gynecological Lesions

What this Trial Is About

Human Papillomavirus HPV infection is the most common sexually transmitted infection worldwide and is linked to approximately 4.5% of all cancers, including most cervical, vaginal, and anal cancers. Women with a history of high-grade HPV-induced gynecological lesions may have an increased risk of developing anal cancer. This research aims to study proctological follow-up for women at risk, based on age, smear results, and HPV tests, to better understand and manage the development of HPV-related anal lesions. This observational study proposes a proctology follow-up protocol for women considered at risk due to their history of high-grade HPV-induced gynecological lesions. The follow-up frequency is tailored according to the patients age and risk factors, occurring every 3 years, 5 years, or annually. The study will observe patients participating in this follow-up to gather data on the risk of developing HPV-induced lesions and to develop a screening and anal follow-up model. Participants will undergo regular proctological examinations and follow-ups as part of the protocol. Researchers will monitor the risk of developing HPV-related lesions over time and assess the effectiveness of the proposed screening model. The study will measure outcomes during the first year and includes ongoing surveillance to improve clinical recommendations. Participants data and health will be observed without intervention, with the study extending until the end of 2032.

Anal Follow-up of Patients With a Gynecological History of High-grade Lesion and More Induced HPV